The neural correlates of tic inhibition in Gilles de la Tourette syndrome
| Autor: | Simone Kühn, Alexander Münchau, Patrick Haggard, Götz Thomalla, Tobias Bäumer, Ursula Kahl, Odette Schunke, Valerie Brandt, Christos Ganos, Veit Roessner |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Male congenital hereditary and neonatal diseases and abnormalities Adolescent Tics Cognitive Neuroscience Prefrontal Cortex Experimental and Cognitive Psychology Motor behaviour Left inferior frontal gyrus Tourette syndrome Young Adult Behavioral Neuroscience On demand mental disorders medicine Humans Neural correlates of consciousness Middle Aged medicine.disease Magnetic Resonance Imaging nervous system diseases body regions Resting state functional magnetic resonance imaging Inhibition Psychological Female Psychology human activities Neuroscience Tourette Syndrome |
| Zdroj: | Neuropsychologia. 65:297-301 |
| ISSN: | 0028-3932 |
| DOI: | 10.1016/j.neuropsychologia.2014.08.007 |
| Popis: | Tics in Gilles de la Tourette syndrome (GTS) resemble fragments of normal motor behaviour but appear in an intrusive, repetitive and context-inappropriate manner. Although tics can be voluntarily inhibited on demand, the neural correlates of this process remain unclear. 14 GTS adults without relevant comorbidities participated in this study. First, tic severity and voluntary tic inhibitory capacity were evaluated outside the scanner. Second, patients were examined with resting state functional magnetic resonance imaging (RS-fMRI) in two states, free ticcing and voluntary tic inhibition. Local synchronization of spontaneous fMRI-signal was analysed with regional homogeneity (ReHo) and differences between both states (free ticcing |
| Databáze: | OpenAIRE |
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