Clinical Characteristics of Patients With Neuromyelitis Optica Spectrum Disorders With Early Onset
| Autor: | Carla Vieira Stella, Thereza Cristina d’Avila Winckler, Nise Alessandra de Carvalho Sousa, Tarso Adoni, Denise Sisterolli Diniz, Tania Saad, Marcus Goncalves, Maria Lucia Vellutini Pimentel, Rinaldo Claudino, Fabiola Rachid Malfetano, Andrea Anacleto, Sidney Gomes, Soniza Vieira Alves-Leon, João Gabriel D. Farinhas, Audred Cristina Biondo Eboni, Alfredo Damasceno, Rhea Sylvia de Souza Mota, Gutemberg Augusto Cruz dos Santos, Yara Dadalti Fragoso |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Adolescent Myelitis Disease Severity of Illness Index 03 medical and health sciences Disability Evaluation Young Adult 0302 clinical medicine medicine Humans Optic neuritis Spectrum disorder Age of Onset Child Retrospective Studies Neuromyelitis optica business.industry Medical record Neuromyelitis Optica Infant medicine.disease eye diseases Middle age Neuromyelitis Optica Spectrum Disorders Child Preschool Pediatrics Perinatology and Child Health 030221 ophthalmology & optometry Disease Progression Female Neurology (clinical) business 030217 neurology & neurosurgery |
| Zdroj: | Journal of child neurology. 34(9) |
| ISSN: | 1708-8283 |
| Popis: | Neuromyelitis optica spectrum disorder is a severe and disabling disease that manifests with severe relapses of optic neuritis, longitudinally extensive myelitis, and/or brainstem syndromes. The disease is complex and, although onset typically occurs in middle age, children and adolescents may be affected. The present study adds to the literature through detailed clinical data from 36 Brazilian patients with neuromyelitis optica spectrum disorder starting before age 21. This was a retrospective assessment of medical records from 14 specialized units in Brazil. The results showed that the course of neuromyelitis optica spectrum disorder was worse in patients with disease onset before the age of 12 years. Gender and ethnic background did not influence disability accumulation. Over a median period of 8 years, 14% of the patients who presented the initial symptoms of neuromyelitis optica spectrum disorder before the age of 21 years died. In conclusion, the present study adds to the reports from other authors examining the severity of early-onset neuromyelitis optica spectrum disorder. |
| Databáze: | OpenAIRE |
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