The Influence of Immunosuppressive Acidic Protein on the Activity of Peripheral K-Lymphocytes in Subacute Thyroiditis
| Autor: | Kaoru Yoshinaga, Toshiro Sakurada, Hiroshi Fukazawa, Yoshida K, Keiji Tamura, Yamamoto M, Saito S, Yoichi Itagaki, Kazuro Kaise, Nobuko Kaise |
|---|---|
| Rok vydání: | 1990 |
| Předmět: |
Adult
Male Thyroid Hormones medicine.medical_specialty Cellular immunity Endocrinology Diabetes and Metabolism Graves' disease Clinical Biochemistry Thyroid Function Tests Biochemistry Thyroiditis Leukocyte Count Sex Factors Endocrinology Immunosuppressive acidic protein Internal medicine Immunopathology medicine Humans Acute-Phase Reaction Thyroiditis Subacute Subacute thyroiditis business.industry Biochemistry (medical) Orosomucoid Middle Aged medicine.disease Graves Disease Pathophysiology Neoplasm Proteins Peripheral Killer Cells Natural C-Reactive Protein Antibody Formation Female business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 71:193-198 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | We previously reported that immunosuppressive acidic protein (IAP), an alpha 1-acid glycoprotein, is increased during the acute phase of subacute thyroiditis (SAT). In this study we measured the percentage and absolute number of peripheral K-cells using a plaque-forming cell technique to investigate immunological abnormalities associated with SAT. Additionally, we investigated the relationship between IAP and peripheral K-cell activity. In normal controls, a sex-related difference in the percentage of K-cells among total lymphocytes was present; the percentage was significantly lower in women (mean +/- SD, 5.0 +/- 2.0%; n = 12; P less than 0.01) than in men (8.4 +/- 2.9%; n = 13). However, there was no difference (0.153 +/- 0.073 x 10(9)/L in five females; 0.173 +/- 0.054 x 10(9)/L in seven males) in the absolute number of peripheral K-cells. During the acute phase of SAT, the percentage (2.4 +/- 1.9% in 16 females; 2.7 +/- 1.0% in 3 males) and absolute number (0.058 +/- 0.048 x 10(9)/L in 11 females) of K-cells were significantly lower than those in normal controls. These values returned to normal during the recovery phase, although their mean values were still lower than those in normal controls. In female patients with Graves' disease, the percentage (2.2 +/- 1.8% in 11 females) and absolute number (0.038 +/- 0.033 x 10(9)/L in 11 females) of K-cells were significantly lower than those in normal controls; in male patients, the percentage (4.2 +/- 2.7% in 5 males) was lower than that in normal controls, but the absolute number (0.136 +/- 0.114 x 10(9)/L) of K-cells was not significantly different. Serum IAP values during the acute phase of SAT showed a significant negative correlation with the percentage of K-cells (r = -0.66; P less than 0.01). The number of K-cells from a normal subject decreased significantly when these lymphocytes were incubated with sera from patients with SAT, and the mean inhibition rate of K-cells by serum samples from 13 SAT patients during the acute phase was higher than that during the recovery phase (68.0 +/- 21.0 vs. 38.0 +/- 23.0%; P less than 0.01). Purified IAP inhibited the activity of K-cells from normal subjects dose dependently. These results suggest that 1) there may be inhibitory factors for the antibody-dependent cell-mediated cytotoxicity of peripheral K-cells in the serum of patients with SAT, and 2) IAP may be one of these inhibitory factors. |
| Databáze: | OpenAIRE |
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