Dually Modified Transmembrane Proteoglycans in Development and Disease
| Autor: | Ben Horst, Carly L. Lancaster, Laura M. Jenkins, Karthikeyan Mythreye |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cell signaling Endocrinology Diabetes and Metabolism Immunology Fibroblast growth factor General Biochemistry Genetics and Molecular Biology Article Syndecan 1 03 medical and health sciences Mice Transforming Growth Factor beta Neoplasms Immunology and Allergy Animals Humans Glycosaminoglycans biology Chemistry Chondroitin Sulfates Wnt signaling pathway Epithelial Cells Transforming growth factor beta Transmembrane protein Cell biology Wnt Proteins 030104 developmental biology Proteoglycan biology.protein Intercellular Signaling Peptides and Proteins Proteoglycans Heparitin Sulfate Syndecan-1 Signal transduction Receptors Transforming Growth Factor beta Signal Transduction |
| Popis: | Aberrant cell signaling in response to secreted growth factors has been linked to the development of multiple diseases, including cancer. As such, understanding mechanisms that control growth factor availability and receptor-growth factor interaction is vital. Dually modified transmembrane proteoglycans (DMTPs), which are classified as cell surface macromolecules composed of a core protein decorated with covalently linked heparan sulfated (HS) and/or chondroitin sulfated (CS) glycosaminoglycan (GAG) chains, provide one type of regulatory mechanism. Specifically, DMTPs betaglycan and syndecan-1 (SDC1) play crucial roles in modulating key cell signaling pathways, such as Wnt, transforming growth factor-β and fibroblast growth factor signaling, to affect epithelial cell biology and cancer progression. This review outlines current and potential functions for betaglycan and SDC1, with an emphasis on comparing individual roles for HS and CS modified DMTPs. We highlight the mutual dependence of DMTPs' GAG chains and core proteins and provide comprehensive knowledge on how these DMTPs, through regulation of ligand availability and receptor internalization, control cell signaling pathways involved in development and disease. |
| Databáze: | OpenAIRE |
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