A maternal methyl-containing diet alters learning ability in the Morris swimming test in adult rats
| Autor: | L. A. Prasolova, I. N. Oskina, I. Z. Plyusnina, O. A. Shchepina, Lyudmila N. Trut |
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| Rok vydání: | 2007 |
| Předmět: |
Male
Nervous system medicine.medical_specialty Spatial Behavior Anxiety Adult offspring Methylation Choline chemistry.chemical_compound Escape Reaction Pregnancy Internal medicine Lactation Male rats medicine Animals Maze Learning Critical Period Psychological General Neuroscience Age Factors Brain Gene Expression Regulation Developmental medicine.disease Animal Feed Rats Betaine medicine.anatomical_structure Endocrinology chemistry Prenatal Exposure Delayed Effects Space Perception Dietary Supplements Spatial learning Female medicine.symptom Psychology |
| Zdroj: | Neuroscience and Behavioral Physiology. 37:425-428 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-007-0030-7 |
| Popis: | Maternal choline diet is known to affect the processes of spatial learning. We report here our studies of learning ability in the Morris swimming test in the adult offspring of maternal rats given a methyl-containing supplement enriched with choline and betaine during pregnancy and lactation. Increases in the time taken to find the invisible platform and the duration of swimming close to the vessel walls were seen, these demonstrating worsening of learning ability in response to the maternal diet. Changes in the platform search strategy were not associated with increases in anxiety in male rats. The possible role of a maternal methyl-containing diet in altering the expression of genes controlling the development of the nervous system is discussed. |
| Databáze: | OpenAIRE |
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