Chlamydia trachomatis, Chlamydial Heat Shock Protein 60 and Anti-Chlamydial Antibodies in Women with Epithelial Ovarian Tumors
| Autor: | Annika Idahl, Jan Olsson, Eva Lundin, Husam Oda, Sarah Jonsson |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Original article Cancer Research Cancer och onkologi endocrine system diseases business.industry Clinical Laboratory Medicine lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens medicine.disease_cause lcsh:RC254-282 female genital diseases and pregnancy complications 03 medical and health sciences Klinisk laboratoriemedicin 030104 developmental biology 0302 clinical medicine Oncology 030220 oncology & carcinogenesis Heat shock protein Cancer and Oncology Immunology medicine Chlamydial antibodies Epithelial ovarian cancer Chlamydia trachomatis business |
| Zdroj: | Translational Oncology Translational Oncology, Vol 11, Iss 2, Pp 546-551 (2018) |
| Popis: | OBJECTIVE: Chlamydia trachomatis (C. trachomatis) infection has been suggested to promote epithelial ovarian cancer (EOC) development. This study sought to explore the presence of C. trachomatis DNA and chlamydial heat shock protein 60 (chsp60) in ovarian tissue, as well as anti-chlamydial IgG antibodies in plasma, in relation to subtypes of EOC. METHODS: This cross-sectional cohort consisted of 69 women who underwent surgery due to suspected ovarian pathology. Ovarian tissue and corresponding blood samples were collected at the time of diagnosis. In ovarian tumor tissue, p53, p16, Ki67 and chsp60 were analyzed immunohistochemically, and PCR was used to detect C. trachomatis DNA. Plasma C. trachomatis IgG and cHSP60 IgG were analyzed with a commercial MIF-test and ELISA, respectively. RESULTS: Eight out of 69 women had C. trachomatis DNA in their ovarian tissue, all were invasive ovarian cancer cases (16.7% of invasive EOC). The prevalence of the chsp60 protein, C. trachomatis IgG and cHSP60 IgG in HGSC, compared to other ovarian tumors, was 56.0% vs. 37.2% P = .13, 15.4% vs. 9.3% P = .46 and 63.6% vs. 45.5% P = .33 respectively. None of the markers of C. trachomatis infection were associated with p53, p16 or Ki67. CONCLUSIONS: C. trachomatis was detected in invasive ovarian cancer, supporting a possible role in carcinogenesis of EOC. However, there were no statistically significant associations of chsp60 in ovarian tissue, or plasma anti-chlamydial IgG antibodies, with any of the subtypes of ovarian tumors. |
| Databáze: | OpenAIRE |
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