Maternal generalized anxiety disorder during pregnancy and fetal brain development: a comparative study on cord blood brain-derived neurotrophic factor levels
| Autor: | Gulsum Sonmez, Kazım Gezginç, Mine Sahingoz, Faruk Uguz, Nazmiye Kaya, Sami Erdem, Erkan Tasyurek, Mustafa Basaran, Humeyra Cicekler, Erdem Onder Sonmez, Zeynel Gokmen |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
endocrine system medicine.medical_specialty Generalized anxiety disorder Physiology Umbilical cord Fetal Development Neurotrophic factors Pregnancy medicine Humans Psychiatry Brain-derived neurotrophic factor Fetus Brain-Derived Neurotrophic Factor Infant Newborn Brain Infant medicine.disease Fetal Blood Anxiety Disorders Pregnancy Complications Psychiatry and Mental health Clinical Psychology medicine.anatomical_structure Cord blood Anxiety Female Pregnant Women medicine.symptom Psychology |
| Zdroj: | Journal of psychosomatic research. 75(4) |
| ISSN: | 1879-1360 |
| Popis: | Objectives The study aimed to investigate whether maternal GAD during pregnancy affects fetal circulating brain-derived neurotrophic factor (BDNF), which plays important roles in neuronal development, by comparing cord blood BDNF levels in newborn infants of women with and without GAD. Methods Study sample included 19 women with GAD and 25 women without any psychiatric disorder. GAD and other psychiatric diagnoses were screened by means of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. The blood sample for the determination of BDNF level was obtained from the umbilical cord during delivery. Results Cord blood BDNF levels in newborn infants of healthy women were approximately two-fold compared to newborn infants of women with GAD, and the difference was statistically significant. The duration of GAD during pregnancy was the only variable correlating with cord blood BDNF levels. Conclusions The study results imply that prolonged maternal GAD during pregnancy may negatively influence neurodevelopment of the fetus through lower levels of circulating BDNF. |
| Databáze: | OpenAIRE |
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