Morphological changes of rat astrocytes induced by liver damage but not by manganese chloride exposure
Autor: | Maricela Méndez-Armenta, Camilo Ríos, Sergio Montes, Pablo Muriel, Susana Rivera-Mancía |
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Rok vydání: | 2008 |
Předmět: |
Male
Pathology medicine.medical_specialty Cirrhosis Striatum Globus Pallidus Liver Cirrhosis Experimental Biochemistry Cellular and Molecular Neuroscience medicine Animals Tissue Distribution Rats Wistar Hepatic encephalopathy Ligation Cerebral Cortex Analysis of Variance Manganese Bile duct Chemistry Liver Cirrhosis Biliary Brain medicine.disease Cortex (botany) Rats Neostriatum Disease Models Animal Globus pallidus medicine.anatomical_structure Cerebral cortex Astrocytes Hepatic Encephalopathy Neurology (clinical) Bile Ducts |
Zdroj: | Metabolic brain disease. 24(2) |
ISSN: | 1573-7365 |
Popis: | Liver cirrhosis is a common cause of death around the world. One of its more severe complications is hepatic encephalopathy. As a consequence of liver impairment, manganese (Mn) and other substances accumulate in the brain. Astrocytic morphological changes have been found in postmortem brains of cirrhotic patients. In this study we used a model of cirrhosis induced by bile duct ligation and Mn accumulation by exposing rats to MnCl(2) (1 mg Mn/ml) in their drinking water. Four experimental groups were used: Sham, Sham plus Mn treatment, BDL (bile duct ligated) and BDL plus Mn treatment. Brain Mn was measured by atomic absorption spectrophotometry in cortex, striatum and globus pallidus. Altered and normal astrocytes were counted in the same brain areas. Brain Mn was highest in rats of the BDLMn group. An increased number of altered astrocytes was found only in BDL groups, Mn did not modify this effect. No changes were found in the total number of astrocytes. According to our results, biliary obstruction induced an increase in the number of altered astrocytes since early stages of cirrhosis and Mn did not affect this effect. |
Databáze: | OpenAIRE |
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