Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options
| Autor: | Peter Heutink, David J. Burn, Bernhard Landwehrmeyer, J. C. van Swieten, S. Wagner, K. A. Frey, Zygmunt Jamrozik, T. Gasser, Günter U. Höglinger, Hans A. Kretzschmar, D. Caparros-Lefebvre, A. Saint-Raymond, Zbigniew K. Wszolek, Jan Kassubek, T. Reum, Markus Otto, Markus Tolnay, A. Kazantsev, Wolfgang H. Oertel, J. J. Lucas, John C. Steele, Stacey Melquist, M. T. Vanier, Dominic C. Paviour, Anthony E. Lang, Eva Maria Mandelkow, Jean Paul G. Vonsattel, Irene Litvan, Hayrettin Tumani, Albert C. Ludolph, Patrick L. McGeer, Kurt A. Jellinger, J. G. de Yebenes, E. M. Mandelkow |
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| Přispěvatelé: | Human genetics, NCA - Neurodegeneration |
| Rok vydání: | 2009 |
| Předmět: |
Tau protein
tau Proteins Protein Serine-Threonine Kinases Leucine-Rich Repeat Serine-Threonine Protein Kinase-2 Models Biological Article Progressive supranuclear palsy Parkinsonian Disorders Pick Disease of the Brain medicine Animals Humans Dementia Corticobasal degeneration Amyotrophic lateral sclerosis Geography biology business.industry Parkinsonism Niemann-Pick Disease Type C medicine.disease Parkinson Disease Postencephalitic Tauopathies Neurology Drug Design Mutation biology.protein Supranuclear Palsy Progressive Neurology (clinical) Tauopathy business Neuroscience Biomarkers Frontotemporal dementia |
| Zdroj: | Ludolph, A C, Kassubek, J, Landwehrmeyer, B G, Mandelkow, E, Mandelkow, E M, Burn, D J, Caparros-Lefebvre, D, Frey, K A, Yebenes, J G, Gasser, T, Heutink, P, Hoglinger, G, Jamrozik, Z, Jellinger, K A, Kazantsev, A, Kretzschmar, H, Lang, A E, Litvan, I, Lucas, J J, McGeer, P L, Melquist, S, Oertel, W, Otto, M, Paviour, D, Reum, T, Saint-Raymond, A, Steele, J C, Tolnay, M, Tumani, H, van Swieten, J C, Vanier, M T, Vonsattel, J P, Wagner, S & Wszolek, Z K 2009, ' Tauopathies with parkinsonism: clinical spectrum, neuropathologic basis, biological markers, and treatment options ', European Journal of Neurology, vol. 16, no. 3, pp. 297-309 . https://doi.org/10.1111/j.1468-1331.2008.02513.x European Journal of Neurology, 16(3), 297-309. Wiley-Blackwell |
| ISSN: | 1468-1331 1351-5101 |
| DOI: | 10.1111/j.1468-1331.2008.02513.x |
| Popis: | Tauopathies with parkinsonism represent a spectrum of disease entities unified by the pathologic accumulation of hyperphosphorylated tau protein fragments within the central nervous system. These pathologic characteristics suggest shared pathogenetic pathways and possible molecular targets for disease-modifying therapeutic interventions. Natural history studies, for instance, in progressive supranuclear palsy, frontotemporal dementia with parkinsonism linked to chromosome 17, corticobasal degeneration, and Niemann-Pick disease type C as well as in amyotrophic lateral sclerosis/Parkinson–dementia complex permit clinical characterization of the disease phenotypes and are crucial to the development and validation of biological markers for differential diagnostics and disease monitoring, for example, by use of neuroimaging or proteomic approaches. The wide pathologic and clinical spectrum of the tauopathies with parkinsonism is reviewed in this article, and perspectives on future advances in the understanding of the pathogenesis are given, together with potential therapeutic strategies. |
| Databáze: | OpenAIRE |
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