Impaired egocentric memory and reduced somatosensory cortex size in temporal lobe epilepsy with hippocampal sclerosis

Autor: Mirjana Ruhleder, Eva Irle, Godehard Weniger, Claudia Lange
Přispěvatelé: University of Zurich, Irle, Eva
Rok vydání: 2012
Předmět:
Adult
Male
Precuneus
Posterior parietal cortex
610 Medicine & health
10056 Clinic for Clinical and Social Psychiatry Zurich West (former)
Neuropsychological Tests
Somatosensory system
Hippocampus
behavioral disciplines and activities
Brain mapping
Functional Laterality
050105 experimental psychology
Temporal lobe
User-Computer Interface
03 medical and health sciences
Behavioral Neuroscience
0302 clinical medicine
2802 Behavioral Neuroscience
Image Processing
Computer-Assisted
medicine
Humans
0501 psychology and cognitive sciences
Maze Learning
Analysis of Variance
Brain Mapping
Memory Disorders
Hippocampal sclerosis
Sclerosis
Postcentral gyrus
05 social sciences
Neuropsychology
Reproducibility of Results
Somatosensory Cortex
Middle Aged
medicine.disease
Magnetic Resonance Imaging
nervous system diseases
medicine.anatomical_structure
Epilepsy
Temporal Lobe
nervous system
Female
Psychology
Neuroscience
psychological phenomena and processes
030217 neurology & neurosurgery
Zdroj: Behavioural Brain Research. 227:116-124
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2011.10.043
Popis: Recent research indicates that longstanding temporal lobe epilepsy (TLE) is associated with extratemporal, i.e. parietal cortex damage. We investigated egocentric and allocentric memory by use of first-person large-scale virtual reality environments in patients with TLE. We expected that TLE patients with parietal cortex damage were impaired in the egocentric memory task. Twenty-two TLE patients with hippocampal sclerosis (HS) and 22 TLE patients without HS were compared with 42 healthy matched controls on two virtual reality tasks affording to learn a virtual park (allocentric memory) and a virtual maze (egocentric memory). Participants further received a neuropsychological investigation and MRI volumetry at the time of the assessment. When compared with controls, TLE patients with HS had significantly reduced size of the ipsilateral and contralateral somatosensory cortex (postcentral gyrus). When compared with controls or TLE patients without HS, TLE patients with HS were severely impaired learning the virtual maze. Considering all participants, smaller volumes of the left-sided postcentral gyrus were related to worse performance on the virtual maze. It is concluded that the paradigm of egocentric navigation and learning in first-person large-scale virtual environments may be a suitable tool to indicate significant extratemporal damage in individuals with TLE.
Databáze: OpenAIRE
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