Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans
| Autor: | Gillian Cockerill, Natzi Sakalihasan, J.L. Martin-Ventura, Jean-Baptiste Michel, Vladislav Treska, Jesús Egido, Jesper Swedenborg, Unnur Thorsteinsdottir, Jes S. Lindholt, Eric Allaire |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adventitial response
Pathology medicine.medical_specialty Physiology Intraluminal thrombus Reviews Atherothrombosis 030204 cardiovascular system & hematology Risk Assessment Pathogenesis 03 medical and health sciences Aortic aneurysm 0302 clinical medicine Aneurysm Risk Factors Physiology (medical) Adventitia medicine.artery medicine Humans Platelet activation cardiovascular diseases Aorta Abdominal Thrombus 030304 developmental biology 0303 health sciences Aorta business.industry Thrombosis medicine.disease Prognosis Abdominal aortic aneurysm 3. Good health medicine.anatomical_structure cardiovascular system Disease Progression Cardiology and Cardiovascular Medicine business Aortic Aneurysm Abdominal |
| Zdroj: | Cardiovascular Research Michel, J-B, Martin-Ventura, J-L, Egido, J, Sakalihasan, N, Treska, V, Lindholt, J S, Allaire, E, Thorsteinsdottir, U, Cockerill, G, Swedenborg, J & For the FAD EU consortium 2011, ' Novel aspects of the pathogenesis of aneurysms of the abdominal aorta in humans ', Cardiovascular Research, vol. 90, no. 1, pp. 18-27 . https://doi.org/10.1093/cvr/cvq337 Cardiovascular Research; Vol 90 |
| ISSN: | 1755-3245 0008-6363 |
| DOI: | 10.1093/cvr/cvq337 |
| Popis: | Aneurysm of the abdominal aorta (AAA) is a particular, specifically localized form of atherothrombosis, providing a unique human model of this disease. The pathogenesis of AAA is characterized by a breakdown of the extracellular matrix due to an excessive proteolytic activity, leading to potential arterial wall rupture. The roles of matrix metalloproteinases and plasmin generation in progression of AAA have been demonstrated both in animal models and in clinical studies. In the present review, we highlight recent studies addressing the role of the haemoglobin-rich, intraluminal thrombus and the adventitial response in the development of human AAA. The intraluminal thrombus exerts its pathogenic effect through platelet activation, fibrin formation, binding of plasminogen and its activators, and trapping of erythrocytes and neutrophils, leading to oxidative and proteolytic injury of the arterial wall. These events occur mainly at the intraluminal thrombus–circulating blood interface, and pathological mediators are conveyed outwards, where they promote matrix degradation of the arterial wall. In response, neo-angiogenesis, phagocytosis by mononuclear cells, and a shift from innate to adaptive immunity in the adventitia are observed. Abdominal aortic aneurysm thus represents an accessible spatiotemporal model of human atherothrombotic progression towards clinical events, the study of which should allow further understanding of its pathogenesis and the translation of pathogenic biological activities into diagnostic and therapeutic applications. |
| Databáze: | OpenAIRE |
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