One-pot precipitation polymerisation strategy for tuneable injectable Laponite®-pNIPAM hydrogels: Polymerisation, processability and beyond
| Autor: | Jonathan Foulkes, Christine L. Le Maitre, Victoria L. Boyes, Christopher Breen, Simon Partridge, Lee A. Fielding, Chris Sammon, Ronak Janani |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Materials science
Polymers and Plastics Precipitation (chemistry) Comonomer Organic Chemistry Thermoresponsive polymers Localised drug delivery Lower critical solution temperature chemistry.chemical_compound Colloid Chemical engineering Polymerization chemistry Regenerative medicine Drug delivery Self-healing hydrogels Materials Chemistry Thermoresponsive polymers in chromatography Injectable hydrogel |
| Zdroj: | Polymer Boyes, V, Janani, R, Fielding, L A, Partridge, S, Breen, C, Foulkes, J, Le Maitre, C & Sammon, C 2021, ' One-pot precipitation polymerisation strategy for tuneable injectable Laponite (R)-pNIPAM hydrogels: Polymerisation, processability and beyond ', Polymer, vol. 233, 124201 . https://doi.org/10.1016/j.polymer.2021.124201 |
| ISSN: | 0032-3861 |
| Popis: | Highly processable hydrogels loaded with active components for localised drug delivery and/or live cells for regenerative medicine are an attractive target for biotechnology research. We describe a single-pot precipitation polymerisation of poly (N-isopropylacrylamide) (pNIPAM) from the surface of dispersed Laponite® platelets in aqueous media above its lower critical solution temperature (LCST), yielding tightly packed pNIPAM globules that resist aggregation and can be maintained for long periods of time as a low viscosity colloidal suspension. Upon cooling, the pNIPAM chains transform from the ‘globule’ to the ‘coil’ conformation, establishing multiple physical interactions and chain entanglement leading to irreversible gel formation. We have shown that the temperature and rate of phase transition and the rheological and mechanical properties of Laponite®-pNIPAM hydrogel can be tailored by addition of N, N′-dimethylacrylamide (DMAc) comonomer and other biologically relevant additives. The tuneable properties of Laponite®-pNIPAM hydrogel confirms its excellent potential for a wide range of therapeutic applications. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect