Pharmacokinetics and Pharmacodynamics of Dexamethasone after Intravenous Administration in Camels: Effect of Dose
| Autor: | M. Lambert, N.A. Al Katheeri, I.A. Wasfi, A. Saeed |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Blood Glucose
medicine.medical_specialty Camelus Hydrocortisone Neutrophils Pharmacology Dexamethasone Pharmacokinetics Internal medicine medicine Animals Lymphocytes IC50 EC50 Volume of distribution Dose-Response Relationship Drug General Veterinary Chemistry Half-life General Medicine Dose–response relationship Endocrinology Pharmacodynamics Injections Intravenous Regression Analysis Female Half-Life Protein Binding medicine.drug |
| Zdroj: | Veterinary Research Communications. 28:525-542 |
| ISSN: | 0165-7380 |
| Popis: | The pharmacokinetics and pharmacodynamics of dexamethasone were evaluated in healthy camels after single intravenous bolus doses of 0.05, 0.1 and 0.2 mg/kg body weight. Dexamethasone showed dose-independent pharmacokinetics. The pharmacokinetic parameters of the two-compartment pharmacokinetic model for the lowest intravenous dose (mean+/-SD) were as follows: terminal elimination half-life 8.17 +/- 1.79 h; total body clearance 100.7 +/- 52.1 (ml/h)/kg; volume of distribution at steady state 0.95 +/- 0.23 L/kg; and volume of the central compartment 0.22 +/- 0.07 L/kg. The extent of plasma protein binding was linear over the concentration range 5-100 ng/ml and averaged 75% +/- 2%. Pharmacodynamic effects were evaluated by measuring endogenous plasma cortisol concentrations, numbers of circulating lymphocytes and neutrophils and plasma glucose concentrations and were analysed using indirect pharmacokinetic/pharmacodynamic models. The cumulative systemic effect increased with dose for markers of pharmacodynamic activity. The estimated IC50 of dexamethasone for cortisol and lymphocytes for the lowest dose were 3.74 +/- 2.44 and 5.58 +/- 8.37 ng/ml, respectively and the EC50 values for neutrophils and glucose were 45.8 +/- 36.9 and 1.17 +/- 0.71 ng/ml, respectively. |
| Databáze: | OpenAIRE |
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