Innate immune evasion strategies of DNA and RNA viruses
| Autor: | Dia C. Beachboard, Stacy M. Horner |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) viruses Biology Microbiology Article 03 medical and health sciences chemistry.chemical_compound Immune system Humans RNA Viruses Receptors Immunologic Gene Transcription factor Immune Evasion Innate immune system Pattern recognition receptor DNA Viruses RNA Virology Immunity Innate 3. Good health 030104 developmental biology Infectious Diseases chemistry Receptors Pattern Recognition Host-Pathogen Interactions Interferon Type I DEAD Box Protein 58 Signal transduction DNA Signal Transduction |
| Zdroj: | Current Opinion in Microbiology |
| ISSN: | 1369-5274 |
| DOI: | 10.1016/j.mib.2016.05.015 |
| Popis: | Upon infection, both DNA and RNA viruses can be sensed by pattern recognition receptors (PRRs) in the cytoplasm or the nucleus to activate antiviral innate immunity. Sensing of viral products leads to the activation of a signaling cascade that ultimately results in transcriptional activation of type I and III interferons, as well as other antiviral genes that together mediate viral clearance and inhibit viral spread. Therefore, in order for viruses to replicate and spread efficiently, they must inhibit the host signaling pathways that induce the innate antiviral immune response. In this review, we will highlight recent advances in the understanding of the mechanisms by which viruses evade PRR detection, intermediate signaling molecule activation, transcription factor activation, and the actions of antiviral proteins. |
| Databáze: | OpenAIRE |
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