Ischemia-induced spreading depolarization in the retina
| Autor: | Eric A. Newman, Anja I. Srienc, Angela M. Shimoda, Joanna Kur, Kyle R. Biesecker |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Subarachnoid hemorrhage Retinal Artery Occlusion Traumatic brain injury Ischemia Biology Retina Brain Ischemia 03 medical and health sciences 0302 clinical medicine medicine Animals Sumatriptan Cortical Spreading Depression Depolarization Original Articles Serotonin 5-HT1 Receptor Agonists Hypoxia (medical) medicine.disease Rats 030104 developmental biology medicine.anatomical_structure Neurology Cortical spreading depression Anesthesia NMDA receptor Neurology (clinical) Dizocilpine Maleate medicine.symptom Cardiology and Cardiovascular Medicine Excitatory Amino Acid Antagonists Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Journal of Cerebral Blood Flow & Metabolism. 36:1579-1591 |
| ISSN: | 1559-7016 0271-678X |
| Popis: | Cortical spreading depolarization is a metabolically costly phenomenon that affects the brain in both health and disease. Following severe stroke, subarachnoid hemorrhage, or traumatic brain injury, cortical spreading depolarization exacerbates tissue damage and enlarges infarct volumes. It is not known, however, whether spreading depolarization also occurs in the retina in vivo. We report now that spreading depolarization episodes are generated in the in vivo rat retina following retinal vessel occlusion produced by photothrombosis. The properties of retinal spreading depolarization are similar to those of cortical spreading depolarization. Retinal spreading depolarization waves propagate at a velocity of 3.0 ± 0.1 mm/min and are associated with a negative shift in direct current potential, a transient cessation of neuronal spiking, arteriole constriction, and a decrease in tissue O2 tension. The frequency of retinal spreading depolarization generation in vivo is reduced by administration of the NMDA antagonist MK-801 and the 5-HT(1D) agonist sumatriptan. Branch retinal vein occlusion is a leading cause of vision loss from vascular disease. Our results suggest that retinal spreading depolarization could contribute to retinal damage in acute retinal ischemia and demonstrate that pharmacological agents can reduce retinal spreading depolarization frequency after retinal vessel occlusion. Blocking retinal spreading depolarization generation may represent a therapeutic strategy for preserving vision in branch retinal vein occlusion patients. |
| Databáze: | OpenAIRE |
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