Outbreak of nosocomial Flavobacterium meningosepticum respiratory infections associated with use of aerosolized polymyxin B
| Autor: | Mary Jo Barker, Michael Sands, Darlene A. Phillips, Daniel Tares, Richard B. Brown, Richard Pleczarka |
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| Rok vydání: | 1989 |
| Předmět: |
Imipenem
Epidemiology medicine.drug_class Antibiotics Erythromycin Microbial Sensitivity Tests Aztreonam medicine.disease_cause Flavobacterium Disease Outbreaks Microbiology chemistry.chemical_compound Ciprofloxacin Administration Inhalation Humans Medicine Polymyxins Respiratory Tract Infections Polymyxin B Cross Infection business.industry Pseudomonas aeruginosa Health Policy Public Health Environmental and Occupational Health Bacterial Infections Hospital Bed Capacity 500 and over medicine.disease Virology Intensive Care Units Pneumonia Infectious Diseases Massachusetts chemistry business medicine.drug |
| Zdroj: | American Journal of Infection Control. 17:121-125 |
| ISSN: | 0196-6553 |
| DOI: | 10.1016/0196-6553(89)90197-1 |
| Popis: | Flavobacterium meningosepticum is an uncommon cause of adult nosocomial infection. On a medical/surgical intensive care unit we recently encountered an adult outbreak of respiratory colonization and infection caused by this organism, which was associated with the prophylactic use of aerosolized polymyxin B that had been used in an attempt to abort an outbreak of infection caused by highly resistant strains of Pseudomonas aeruginosa. Twenty isolates (95% from respiratory secretions) of F. meningosepticum from nine persons were identified during a 2 1/2-month period. No environmental source has been identified to date. Pneumonia developed in five patients, and two deaths associated with this organism occurred. All isolates were sensitive to ciprofloxacin; none were sensitive to other antibiotics tested, including third-generation cephalosporins, aminoglycosides, erythromycin, trimethoprim-sulfamethoxazole, antipseudomonal penicillins, aztreonam, and imipenem/cilastatin. Two patients with nosocomial pneumonia were successfully treated with oral ciprofloxacin. F. meningosepticum may emerge as an important pathogen if prophylactic use of polymyxin B becomes more widespread. Ciprofloxacin may become the agent of choice for treatment of this organism. |
| Databáze: | OpenAIRE |
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