Association of concurrent porcine circovirus (PCV) 2a and 2b infection with PCV associated disease in vaccinated pigs
| Autor: | Priscilla F. Gerber, John K. Johnson, Chao-Ting Xiao, Patrick G. Halbur, Huigang Shen, Dave Striegel, Tanja Opriessnig |
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| Rok vydání: | 2013 |
| Předmět: |
Circovirus
Swine animal diseases Disease Outbreaks Immune system Mycoplasma hyopneumoniae Animals Medicine Porcine circovirus associated disease Circoviridae Infections Phylogeny Swine Diseases General Veterinary biology business.industry virus diseases Viral Vaccines biology.organism_classification Virology United States Vaccination Porcine circovirus Immunology Herd biology.protein Antibody business Vaccine failure |
| Zdroj: | Research in Veterinary Science. 95:775-781 |
| ISSN: | 0034-5288 |
| Popis: | Investigations were performed to characterize porcine circovirus (PCV) 2 infection in 10 week old pigs from a case of apparent vaccine failure. Thirty serum samples were collected from affected or non-affected pigs and tested for anti-PCV2 antibodies and PCV2 DNA. To address potential PCV2 vaccine compliance issues, samples were tested for antibodies against baculovirus and Mycoplasma hyopneumoniae antigens present in the PCV2 vaccine utilized in this herd. Both PCV2a and PCV2b DNA were detected in 76.6% (90% positive for PCV2a, 86.6% positive for PCV2b), anti-PCV2 IgG in 90%, anti-baculovirus IgG in 50%, and anti-M. hyopneumoniae IgG in 43.3% of the samples. Frequency of baculovirus and M. hyopneumoniae seropositive pigs was significantly lower in affected pigs. The finding that only 50% of the pigs developed a detectable immune response to vaccination suggests poor vaccine compliance or efficacy. Concurrent PCV2a and PCV2b infection was common and may have resulted in enhanced PCV2 replication. |
| Databáze: | OpenAIRE |
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