High prevalence of ST121 in community-associated methicillin-susceptible Staphylococcus aureus lineages responsible for skin and soft tissue infections in Portuguese children

Autor: Teresa Sardinha, Teresa Conceição, Marta Aires-de-Sousa, Maria João Brito, C. Barradas, H. de Lencastre, Luisa Sancho, Roberta Paula Schell Coelho, N. Pona, G. de Sousa, M. do Céu Machado
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Microbiology (medical)
clone (Java method)
medicine.medical_specialty
Staphylococcus aureus
Genotype
Virulence Factors
Leukocidin
Virulence
Criança
Biology
medicine.disease_cause
Infecções comunitárias adquiridas
Microbiology
03 medical and health sciences
0302 clinical medicine
Medical microbiology
Leukocidins
medicine
Pulsed-field gel electrophoresis
Prevalence
Humans
Infecções dos tecidos moles
030212 general & internal medicine
Soft tissue infections
Child
0303 health sciences
Portugal
030306 microbiology
Soft Tissue Infections
General Medicine
biochemical phenomena
metabolism
and nutrition
bacterial infections and mycoses
3. Good health
Bacterial Typing Techniques
Electrophoresis
Gel
Pulsed-Field
Community-Acquired Infections
Molecular Typing
Infectious Diseases
Child
Preschool
Staphylococcal Skin Infections
Methicillin Susceptible Staphylococcus Aureus
Zdroj: European Journal of Clinical Microbiology & Infectious Diseases; Vol 30
European Journal of Clinical Microbiology & Infectious Diseases
ISSN: 1435-4373
DOI: 10.1007/s10096-010-1087-8
Popis: In order to evaluate the incidence of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) in Portugal, we analyzed a collection of 38 S. aureus isolates recovered from 30 children attending the pediatric emergency department of a central hospital in Lisbon due to skin and soft tissue infections. Molecular characterization identified seven clonal lineages among the 35 methicillin-susceptible S. aureus (MSSA) isolates, of which the major lineage PFGE A/t159/ST121 included 63% of the isolates. The three MRSA isolates belonged to the Pediatric clone PFGE D/t535/ST5-IV (n = 2) and to the European CA-MRSA clone PFGE G/t044/ST80-IVc (n = 1). All isolates harbored several virulence factors, namely, leukocidins. Panton–Valentine leukocidin (PVL) was produced by isolates from five MSSA lineages and by the ST80 MRSA. Of interest, this is the first reported isolation of CA-MRSA ST80 in Portugal.
Databáze: OpenAIRE
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