Terminal Schwann cells elaborate extensive processes following denervation of the motor endplate
| Autor: | Clifford J. Woolf, M.L. Reynolds |
|---|---|
| Rok vydání: | 1992 |
| Předmět: |
Histology
Nerve Crush Calcitonin Gene-Related Peptide Schwann cell Biology Motor Endplate Neuromuscular junction Perisynaptic schwann cells medicine Animals Low-affinity nerve growth factor receptor Nerve Growth Factors Denervation Muscles General Neuroscience S100 Proteins Rats Inbred Strains Cell Biology Immunohistochemistry Sciatic Nerve Axons Nerve Regeneration Rats medicine.anatomical_structure Nerve growth factor nervous system Antigens Surface Nerve Degeneration Thy-1 Antigens Schwann Cells Anatomy Neuroscience Reinnervation |
| Zdroj: | Journal of Neurocytology. 21:50-66 |
| ISSN: | 1573-7381 0300-4864 |
| DOI: | 10.1007/bf01206897 |
| Popis: | Terminal Schwann cells, when stained for S100 (a calcium binding protein), can be seen to cap motor axons at the neuromuscular junction. Within days of denervation the Schwann cells begin to stain for the low affinity nerve growth factor receptor, but remain Thy-1 negative, and elaborate fine processes. These processes become longer and more disorganized over weeks, and cells positive for S100 and nerve growth factor receptor migrate into the perisynaptic area. Reinnervation results in a withdrawal of the processes. The morphology and location of terminal Schwann cells seems to depend on axonal contact. The spread of Schwann cells and their processes away from the synaptic zone following denervation, implies that these cells do not target axons directly to the endplate. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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