Identification of a Novel Genomic Island Associated with vanD-Type Vancomycin Resistance in Six Dutch Vancomycin-Resistant Enterococcus faecium Isolates
| Autor: | Jukka Corander, Erik Bathoorn, Rob J. L. Willems, Jan C. Sinnige, Rogier Jansen, Ellen C. Brouwer, Guido Werner, Janetta Top, Juliëtte A. Severin, John W. A. Rossen, Marc J. M. Bonten |
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| Přispěvatelé: | Jukka Corander / Principal Investigator, Department of Mathematics and Statistics, Biostatistics Helsinki, Microbes in Health and Disease (MHD), Medical Microbiology & Infectious Diseases |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
GENE-CLUSTER Genomic Islands VanD type 030106 microbiology Enterococcus faecium Microbial Sensitivity Tests Biology Epidemiology and Surveillance 03 medical and health sciences vanD type genomic island Bacterial Proteins Vancomycin Phylogenetics Genomic island Genetic variation Gene cluster Journal Article medicine Pharmacology (medical) MOLECULAR CHARACTERIZATION Phylogeny 1183 Plant biology microbiology virology Pharmacology Genetics Phylogenetic tree FLORA biochemical phenomena metabolism and nutrition Commensalism biology.organism_classification Anti-Bacterial Agents Infectious Diseases FAECALIS CANADA vancomycin resistance Multigene Family CONJUGATIVE ELEMENTS Vancomycin resistance medicine.drug |
| Zdroj: | Antimicrobial Agents and Chemotherapy, 62(3):e01793-17. AMER SOC MICROBIOLOGY Antimicrobial Agents & Chemotherapy, 62(3):e01793-17. American Society for Microbiology Antimicrobial Agents and Chemotherapy, 62(3). American Society for Microbiology |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Genomic comparison of the first six Dutch vanD -type vancomycin-resistant Enterococcus faecium (VRE) isolates with four vanD gene clusters from other enterococcal species and anaerobic gut commensals revealed that the vanD gene cluster was located on a genomic island of variable size. Phylogenetic inferences revealed that the Dutch VRE isolates were genetically not closely related and that genetic variation of the vanD -containing genomic island was not species specific, suggesting that this island is transferred horizontally between enterococci and anaerobic gut commensals. |
| Databáze: | OpenAIRE |
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