Regulation of trace elements and redox status in striatum of adult rats by long-term aerobic exercise depends on iron uptakes
| Autor: | De-Sheng Xiao, Hua-Bo Wu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Iron Overload Antioxidant Iron medicine.medical_treatment Striatum Rats Sprague-Dawley Superoxide dismutase 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Animal science Malondialdehyde Physical Conditioning Animal medicine Animals Aerobic exercise biology Superoxide Dismutase Chemistry General Neuroscience Trace element Iron Deficiencies Iron deficiency medicine.disease Corpus Striatum Rats Trace Elements 030104 developmental biology Biochemistry biology.protein Female Hydroxyl radical Oxidation-Reduction Iron Dietary 030217 neurology & neurosurgery |
| Zdroj: | Neuroscience Letters. 642:66-70 |
| ISSN: | 0304-3940 |
| DOI: | 10.1016/j.neulet.2017.01.070 |
| Popis: | We investigated the effects of aerobic exercise (AE) on trace element contents and redox status in the striatum of rats with different diet iron. Weaned female rats were randomly fed with iron-adequate diet (IAD), iron-deficient diet (IDD), and iron-overloaded diet (IOD). After feeding their respective diet for 1 month, the rats fed with same diet were divided into swimming and maintaining sedentary (S) group. After 3 months, the non-heme iron (NHI), Mn, Cu, and Zn in the striatum were measured. Meanwhile, malonaldehyde acid (MDA), total superoxide dismutase activity, hydroxyl radical scavenging activity, and total antioxidant capacity were also analyzed. As compared with respective S rats, Mn, Cu, and Zn contents were significantly decreased in IDDE, but no significantly changes could be seen in IADE or IODE. A negative correlation of NHI with Cu contents in IDDE and positive correlations of NHI with Cu, or Zn contents in IADE, or with Mn or Cu contents in IODE were observed. In addition, striatum MDA was significantly decreased and anti-oxidative variables were increased in IODE compared to IODS. Our results suggest that the modification of trace elements and redox status in the striatum of rats caused by AE depends on dietary iron contents and that AE may also regulate the metabolic relationship of iron storage with other trace elements. |
| Databáze: | OpenAIRE |
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