High-speed optical coherence tomography angiography for the measurement of stimulus-induced retrograde vasodilation of cerebral pial arteries in awake mice
| Autor: | Yong Jeong, Jin-Hui Yoon, Paul Shin, Wang-Yuhl Oh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Letter Haemodynamic response Neuroscience (miscellaneous) Hemodynamics Vasodilation Stimulus (physiology) 01 natural sciences 010309 optics 03 medical and health sciences retrograde vasodilation 0302 clinical medicine Neuroimaging Optical coherence tomography Internal medicine 0103 physical sciences Medicine Radiology Nuclear Medicine and imaging angiography Neurophotonics Letters optical coherence tomography Radiological and Ultrasound Technology medicine.diagnostic_test business.industry Optical coherence tomography angiography Angiography Cardiology cardiovascular system awake imaging functional hyperemia business 030217 neurology & neurosurgery |
| Zdroj: | Neurophotonics |
| ISSN: | 2329-423X |
| Popis: | Significance: Having a clear understanding of functional hyperemia is crucial for functional brain imaging and neurological disease research. Vasodilation induced by sensory stimulus propagates from the arterioles to the upstream pial arteries in a retrograde fashion. As retrograde vasodilation occurs briefly in the early stage of functional hyperemia, an imaging technique with a high temporal resolution is required for its measurement. Aim: We aimed to present an imaging method to measure stimulus-induced retrograde vasodilation in awake animals. Approach: An imaging method based on optical coherence tomography angiography, which enables a high-speed and label-free vessel diameter measurement, was developed and applied for the investigation. Results: The propagation speed of retrograde vasodilation of pial artery was measured in awake mice. Other characteristics of functional hyperemia such as temporal profile and amplitude of the vascular response were also investigated. Conclusions: Our results provide detailed information of stimulus-induced hemodynamic response in the brain of awake mice and suggest the potential utility of our imaging method for the study of functional hyperemia in normal and diseased brain. |
| Databáze: | OpenAIRE |
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