Very Late–Onset Dabigatran-Induced Esophageal Injury
| Autor: | Shinya Minatoguchi, Ko Fujikawa, Nobuhiro Takasugi, Tadao Goto |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Late onset Antithrombins Dabigatran 03 medical and health sciences 0302 clinical medicine Internal medicine Atrial Fibrillation medicine Humans Endoscopy Digestive System Esophagus Aged 80 and over medicine.diagnostic_test Esophagogastroduodenoscopy business.industry Heartburn Dysphagia Endoscopy Surgery medicine.anatomical_structure Esophageal Stenosis cardiovascular system Cardiology 030211 gastroenterology & hepatology medicine.symptom Tomography X-Ray Computed Cardiology and Cardiovascular Medicine business Complication 030217 neurology & neurosurgery Follow-Up Studies medicine.drug |
| Zdroj: | Canadian Journal of Cardiology. 33:554.e15-554.e16 |
| ISSN: | 0828-282X |
| DOI: | 10.1016/j.cjca.2016.12.017 |
| Popis: | An 87-year-old man with persistent atrial fibrillation experienced heartburn and dysphagia at 2 years 9 months after initiation of dabigatran. An esophagogastroduodenoscopy demonstrated multiple longitudinal white plaques with ulcers in the narrowed midesophagus compressed between the left atrium and the tortuous aorta. We speculate that the esophageal stenosis contributed to stasis of dabigatran within the esophagus, resulting in prolonged mucosal contact with the caustic contents of the drug. Progressive enlargement of the left atrium may have led to the late onset of the potentially serious complication. |
| Databáze: | OpenAIRE |
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