Low-cost assays for monitoring HIV infected individuals in resource-limited settings
| Autor: | Suniti Solomon, Sunil S. Solomon, Saravanan Shanmugham, Pachamuthu Balakrishnan, Hussain Syed Iqbal, Janardhanan Mohanakrishnan, Kenneth H. Mayer |
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| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
resource-limited settings Human immunodeficiency virus (HIV) HIV Infections Review Article CD4 count medicine.disease_cause General Biochemistry Genetics and Molecular Biology Plasma viral load Monitoring Immunologic Hiv infected Humans Medicine plasma viral load Intensive care medicine Developing Countries low-cost assays HIV monitoring business.industry Disease progression General Medicine Viral Load Standard methods Prognosis Antiretroviral therapy CD4 Lymphocyte Count Immunology Disease Progression HIV-1 business Limited resources Viral load |
| Zdroj: | The Indian Journal of Medical Research Scopus-Elsevier |
| ISSN: | 0971-5916 |
| DOI: | 10.4103/0971-5916.92628 |
| Popis: | Use of a combination of CD4 counts and HIV viral load testing in the management of antiretroviral therapy (ART) provides higher prognostic estimation of the risk of disease progression than does the use of either test alone. The standard methods to monitor HIV infection are flow cytometry based for CD4+ T cell count and molecular assays to quantify plasma viral load of HIV. Commercial assays have been routinely used in developed countries to monitor ART. However, these assays require expensive equipment and reagents, well trained operators, and established laboratory infrastructure. These requirements restrict their use in resource-limited settings where people are most afflicted with the HIV-1 epidemic. With the advent of low-cost and/or low-tech alternatives, the possibility of implementing CD4 count and viral load testing in the management of ART in resource-limited settings is increasing. However, an appropriate validation should have been done before putting them to use for patient testing. |
| Databáze: | OpenAIRE |
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