Beta-Glucan based temperature responsive hydrogels for 5-ASA delivery
| Autor: | Vildan Betul Yenigun, Mehmet S. Eroglu, Fatemeh Bahadori, Aysen Eyigor |
|---|---|
| Přispěvatelé: | BAHADORİ, FATEMEH |
| Rok vydání: | 2018 |
| Předmět: |
Thermogravimetric analysis
Hot Temperature beta-Glucans Polymers and Plastics Biocompatibility macromolecular substances 02 engineering and technology 010402 general chemistry complex mixtures 01 natural sciences Cell Line chemistry.chemical_compound Drug Delivery Systems Differential scanning calorimetry Materials Chemistry medicine Humans Thermal stability EYIGOR A. Bahadori F. Yenigun V. B. EROGLU M. -Beta-Glucan based temperature responsive hydrogels for 5-ASA delivery.- Carbohydrate polymers cilt.201 ss.454-463 2018 Mesalamine Chemistry Organic Chemistry technology industry and agriculture Hydrogels Potassium persulfate 021001 nanoscience & nanotechnology 0104 chemical sciences Polymerization Chemical engineering Self-healing hydrogels Swelling medicine.symptom 0210 nano-technology |
| Zdroj: | Carbohydrate Polymers. 201:454-463 |
| ISSN: | 0144-8617 |
| Popis: | A series of temperature responsive hydrogels consisting of (1,3)-(1,6) beta-Glucan and poly (N-isopropyl acrylamide) (PNIPAM) was synthesized by redox polymerization at room temperature. Tetramethylethylenediamine (TEMED) and potassium persulfate (KPS) were used as a redox pair. beta-glucan was methacrylated (MA-beta-Glucan) and used as a biodegradable and bio-compatible cross-linker to prepare beta-glucan-PNIPAM based temperature responsive hydrogels. Swelling behavior of the hydrogels at different temperatures was investigated. The 5-ASA release from the hydrogels was monitored using UV-VIS spectrophotometer at 37 degrees C. It is notable that, the swelling and release behaviors of the hydrogels significantly change depending on the hydrogel compositions and temperature. Their thermal stability was determined using thermogravimetric analysis (TGA), assuming the extent of intermolecular interaction between PNIPAM and beta-glucan is proportional to thermal stability, which increased with the amount of PNIPAM. Volume phase transition temperature (VPTT) of the hydrogels was precisely determined by derivative differential scanning calorimeter (DDSC). They possessed variable VPTT with the compositions. The presence of beta-glucan in the PNIPAM network brought VPTT closer to the body temperature (from 32.8 degrees C to 35.5 degrees C), indicating that the VPTT could be tuned by the hydrogel compositions. Their in-vivo biocompatibility was tested against WS1 human fibroblast cells in phosphate buffer saline (PBS, pH 7.4). It was demonstrated that, using MA-beta-glucan as a cross-linker resulted in more bio-compatible thermo-responsive hydrogels indicating the enhancement of hydrophilic beta-Glucan on the swollen hydrogel surface. |
| Databáze: | OpenAIRE |
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