The decreased availability of L-tryptophan in depressed females: Clinical and biological correlates
| Autor: | Chris Schotte, Simon Scharpé, Maurits Vandewoude, M. Martin, P. Blockx, Michael Maes, Peter D'Hondt |
|---|---|
| Přispěvatelé: | Personality and Social Psychology, Vrije Universiteit Brussel, Clinical Biology |
| Rok vydání: | 1990 |
| Předmět: |
Adult
medicine.medical_specialty Hydrocortisone Phenylalanine Urine Adrenocorticotropic hormone Dexamethasone Norepinephrine Vanilmandelic Acid Adrenocorticotropic Hormone Internal medicine Blood plasma medicine Humans Amino Acids Biological Psychiatry Pharmacology Analysis of Variance Depressive Disorder Depression Tryptophan Middle Aged Thyroxine Endocrinology Dexamethasone suppression test Multivariate Analysis Regression Analysis Triiodothyronine Female Isoleucine Psychology Glucocorticoid Hormone medicine.drug |
| Zdroj: | Scopus-Elsevier Vrije Universiteit Brussel |
| ISSN: | 0278-5846 |
| DOI: | 10.1016/0278-5846(90)90076-s |
| Popis: | Maes, Michael, Maurits Vandewoude, Chris Schotte, Manuella Martin, Peter D'Hondt, Simon Scharpe and Pierre Blockx: The Decreased Availability of L-Tryptophan in Depressed Females: Clinical and Biological Correlates. Prog. Neuro-Psychopharmacol. & Biol. Psychiat. 1990, 14 : 903–919. 1. 1. The plasma levels of L-tryptophan (L-TRP) and the sum of five competing amino acids (CAA) namely tyrosine, phenylalanine, vallne, leucine, isoleucine, were determined in 79 depressed females categorized according to the DSM-III. 2. 2. In these patients the authors measured several parameters known to affect the availability of the above amino acids i.e. triidothyronine (FT 3 ) and thyroxlne (FT 4 ), vanilylmandelic acid (VMA), noradrenaline and adrenaline in 24 hr urine, the sex hormonal and nutritional state. 3. 3. The 1 mg dexamethasone suppression test was performed and the pre and postdexamethasone cortisol and adrenocorticotropic hormone (ACTH) levels were determined at 8 a.m. 4. 4. L-TRP and the ratio L-TRP/CAA were significantly lower in severely depressed females (296. × 3, 296. × 4) as compared with minor (300.40, 309.00) and simple major depressives (296. × 2). The ratio L-TRP/CAA performed well as a clinical tool separating melancholic from minor depression. 5. 5. FT 3 , FT 4 , VMA and noradrenaline were significantly increased in the severely depressed females, but these data did not correlate with the availability of L-TRP. Neither baseline cortisol nor the sex hormonal, nor the nutritional state related to the L-TRP data. The ratio L-TRP/CAA was significantly and negatively correlated with the postdexamethasone cortisol and ACTH values. |
| Databáze: | OpenAIRE |
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