Homocysteine levels and decline in physical function: MacArthur Studies of Successful Aging
| Autor: | Jacob Selhub, Teresa E. Seeman, Deborah M. Kado, Alexander Bucur, John W. Rowe |
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| Rok vydání: | 2002 |
| Předmět: |
Male
Risk medicine.medical_specialty Aging Homocysteine chemistry.chemical_compound Internal medicine medicine Odds Ratio Humans Prospective Studies Prospective cohort study Stroke Gait Postural Balance Balance (ability) Aged Successful aging business.industry General Medicine Odds ratio medicine.disease Confidence interval chemistry Quartile Motor Skills Physical therapy Linear Models Female business Biomarkers Psychomotor Performance Muscle Contraction |
| Zdroj: | The American journal of medicine. 113(7) |
| ISSN: | 0002-9343 |
| Popis: | Purpose To test whether elevated homocysteine levels are associated with an increased risk of decline in physical function in older persons. Methods We performed a prospective cohort study of 499 highly functioning men and women aged 70 to 79 years who were enrolled in the MacArthur Studies of Successful Aging. We measured total homocysteine levels and performance-based physical function at baseline; physical function measures were repeated an average of 28 months later. A summary measure of physical performance from tests of balance, gait, lower body strength and coordination, and manual dexterity was developed, and a change score was calculated as the difference in scores from 1988 to 1991. Results The mean (±SD) homocysteine level was 11.6 ± 4.3 μmol/L. With each SD increase in homocysteine, there was an increased risk of being in the worst quartile of decline in physical function (odds ratio=1.5; 95% confidence interval: 1.2 to 1.9) in analyses that adjusted for age, sex, baseline physical performance, smoking status, vitamin B 12 levels, and incident stroke. Similar results were seen when change in physical performance was treated as a continuous variable. Conclusion Older persons with elevated plasma homocysteine levels are at an increased risk of decline in physical function. |
| Databáze: | OpenAIRE |
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