Analysis of the effects of subthalamic nucleus deep brain stimulation on somatosensation in Parkinson's disease patients

Autor: Esra Okuyucu, Atilla Yilmaz, Esra Dogru Huzmeli
Rok vydání: 2019
Předmět:
Adult
Male
medicine.medical_specialty
Parkinson's disease
Deep brain stimulation
Movement disorders
Neurology
Graphesthesia
medicine.medical_treatment
Deep Brain Stimulation
Dermatology
Somatosensory system
behavioral disciplines and activities
Perceptual Disorders
03 medical and health sciences
Two-point discrimination
0302 clinical medicine
Physical medicine and rehabilitation
Discrimination
Psychological
Subthalamic Nucleus
medicine
Humans
Thermosensing
030212 general & internal medicine
Kinesthesis
Aged
business.industry
Pain Perception
Parkinson Disease
General Medicine
Middle Aged
medicine.disease
Proprioception
nervous system diseases
Psychiatry and Mental health
Subthalamic nucleus
surgical procedures
operative
nervous system
Touch Perception
Female
Neurology (clinical)
medicine.symptom
business
therapeutics
030217 neurology & neurosurgery
Zdroj: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 41(4)
ISSN: 1590-3478
Popis: Despite the subthalamic nucleus (STN) deep brain stimulation (DBS) is a treatment commonly used to ameliorate the motor symptoms of Parkinson’s disease (PD), its effects on somatosensation is unclear. The purpose of this study was to investigate the potential effects of DBS on temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and odor identification in PD patients. The study included 14 patients (with a mean age of 59.78 ± 11.03 years; range, 44–70 years) with idiopathic PD who underwent DBS surgery for movement disorders caused by PD at the same Neurosurgery Department. All patients were tested while DBS was turned on (DBS-ON) and off (DBS-OFF). To clearly observe the effect of removing stimulation off, DBS devices were turned off by experimental clinical personnel for a minimum duration of 30 min prior to examination. Temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and odor identification were examined. We found that two-point discrimination was significantly lower during DBS-ON than DBS-OFF (p = 0.031). Tactile sensation and kinesthesia deviation degree were lower during DBS-ON than DBS-OFF, but were non-significant (p > 0.05). The number of correct answers on an assessment of graphesthesia was higher during DBS-ON, but was non-significant as well (p > 0.05). Odor identification was better during DBS-OFF. DBS may have an effective role to improve somatosensation and DBS-related benefits may not be explained by improvements in motor function alone, but rather by enhanced somatosensory processing. Further studies with larger study groups are needed.
Databáze: OpenAIRE
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