Analysis of the effects of subthalamic nucleus deep brain stimulation on somatosensation in Parkinson's disease patients
Autor: | Esra Okuyucu, Atilla Yilmaz, Esra Dogru Huzmeli |
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Rok vydání: | 2019 |
Předmět: |
Adult
Male medicine.medical_specialty Parkinson's disease Deep brain stimulation Movement disorders Neurology Graphesthesia medicine.medical_treatment Deep Brain Stimulation Dermatology Somatosensory system behavioral disciplines and activities Perceptual Disorders 03 medical and health sciences Two-point discrimination 0302 clinical medicine Physical medicine and rehabilitation Discrimination Psychological Subthalamic Nucleus medicine Humans Thermosensing 030212 general & internal medicine Kinesthesis Aged business.industry Pain Perception Parkinson Disease General Medicine Middle Aged medicine.disease Proprioception nervous system diseases Psychiatry and Mental health Subthalamic nucleus surgical procedures operative nervous system Touch Perception Female Neurology (clinical) medicine.symptom business therapeutics 030217 neurology & neurosurgery |
Zdroj: | Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. 41(4) |
ISSN: | 1590-3478 |
Popis: | Despite the subthalamic nucleus (STN) deep brain stimulation (DBS) is a treatment commonly used to ameliorate the motor symptoms of Parkinson’s disease (PD), its effects on somatosensation is unclear. The purpose of this study was to investigate the potential effects of DBS on temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and odor identification in PD patients. The study included 14 patients (with a mean age of 59.78 ± 11.03 years; range, 44–70 years) with idiopathic PD who underwent DBS surgery for movement disorders caused by PD at the same Neurosurgery Department. All patients were tested while DBS was turned on (DBS-ON) and off (DBS-OFF). To clearly observe the effect of removing stimulation off, DBS devices were turned off by experimental clinical personnel for a minimum duration of 30 min prior to examination. Temperature, proprioceptive, tactile, exteroceptive, pain and cortical sensations, and odor identification were examined. We found that two-point discrimination was significantly lower during DBS-ON than DBS-OFF (p = 0.031). Tactile sensation and kinesthesia deviation degree were lower during DBS-ON than DBS-OFF, but were non-significant (p > 0.05). The number of correct answers on an assessment of graphesthesia was higher during DBS-ON, but was non-significant as well (p > 0.05). Odor identification was better during DBS-OFF. DBS may have an effective role to improve somatosensation and DBS-related benefits may not be explained by improvements in motor function alone, but rather by enhanced somatosensory processing. Further studies with larger study groups are needed. |
Databáze: | OpenAIRE |
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