Role for Nonstructural Protein 1 of Severe Acute Respiratory Syndrome Coronavirus in Chemokine Dysregulation
| Autor: | Hch Yim, Asy Lau, Ahy Law, Dcw Lee, Bkw Cheung |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Chemokine
viruses Immunology CCL3 Cellular Response to Infection Respiratory Mucosa Biology Viral Nonstructural Proteins medicine.disease_cause Microbiology CCL5 Viral Matrix Proteins Viral Envelope Proteins Virology medicine Viral structural protein CXCL10 Coronaviridae Chemokine CCL5 Coronavirus Chemokine CCL3 Viral matrix protein Errata business.industry NF-kappa B virus diseases Immune dysregulation biology.organism_classification Chemokine CXCL10 Gene Expression Regulation Severe acute respiratory syndrome-related coronavirus Insect Science Chemokines CC biology.protein Severe acute respiratory syndrome coronavirus Chemokines business Chemokines CXC |
| Zdroj: | Journal of Virology |
| ISSN: | 0022-538X |
| DOI: | 10.1128/jvi.02336-05 |
| Popis: | Severe acute respiratory syndrome (SARS) is an emerging infectious disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-κB. |
| Databáze: | OpenAIRE |
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