Presence of intracranial artery calcification is associated with mortality and vascular events in patients with ischemic stroke after hospital discharge: a cohort study

Autor: Claire Leclercq, Jean-Marc Chillon, C. Lamy, Hervé Deramond, Jean-Marc Bugnicourt, Momar Diouf, Ziad A. Massy, Sandrine Canaple, Olivier Godefroy
Přispěvatelé: Service de neurologie [Amiens], CHU Amiens-Picardie, Laboratoire de Neurosciences Fonctionnelles et Pathologies, Université de Picardie Jules Verne (UPJV)-Faculté de Médecine Henri Warembourg - Université de Lille, Affectations Mineralisantes du Systeme Cardiovasculaire : Calcifications Arterielles et Valvulaires Aortiques, Université de Picardie Jules Verne (UPJV)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Biostatistiques [Amiens], Service de Radiologie [Amiens], Services de Pharmacologie Clinique et Néphrologie, Université de Picardie Jules Verne (UPJV)-Université Lille 2 - Faculté de Médecine -Université Charles de Gaulle - Lille 3
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Male
Cerebral arteries
030204 cardiovascular system & hematology
MESH: Calcinosis
Brain Ischemia
0302 clinical medicine
MESH: Aged
80 and over
Risk Factors
MESH: Risk Factors
Stroke
MESH: Cerebral Arteries
Aged
80 and over
MESH: Aged
MESH: Middle Aged
Calcinosis
MESH: Brain Ischemia
Intracranial Artery
MESH: Follow-Up Studies
Middle Aged
Prognosis
stroke
Patient Discharge
3. Good health
calcifications
Cardiology
outcome
all-cause mortality
Female
MESH: Cerebrovascular Disorders
[SDV.IB]Life Sciences [q-bio]/Bioengineering
Cardiology and Cardiovascular Medicine
Cohort study
Adult
cardiovascular risk
medicine.medical_specialty
acute stroke
MESH: Prognosis
MESH: Stroke
03 medical and health sciences
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Hounsfield scale
Internal medicine
medicine
Humans
Risk factor
Aged
Advanced and Specialized Nursing
MESH: Humans
business.industry
MESH: Patient Discharge
MESH: Adult
Cerebral Arteries
medicine.disease
MESH: Male
Surgery
Radiography
Cerebrovascular Disorders
Ischemic stroke
Neurology (clinical)
business
MESH: Female
030217 neurology & neurosurgery
Calcification
Follow-Up Studies
Zdroj: Stroke
Stroke, 2011, 42 (12), pp.3447-53. ⟨10.1161/STROKEAHA.111.618652⟩
Stroke, American Heart Association, 2011, 42 (12), pp.3447-53. ⟨10.1161/STROKEAHA.111.618652⟩
ISSN: 0039-2499
1524-4628
DOI: 10.1161/STROKEAHA.111.618652⟩
Popis: Background and Purpose— Although intracranial artery calcification (IAC) has been reported to be a risk factor for ischemic stroke, the prognostic implications of IAC in stroke outcome are unknown. The purpose of this study was to determine the association between IAC and risk of vascular events and death in patients with stroke after hospital discharge. Methods— All patients with ischemic stroke over a 1-year period were included (n=302). IAC, assessed by multidetector CT, was defined as hyperdense foci (peak density >130 Hounsfield units) and assessed in the 7 major cerebral arteries. The IAC scores ranged from 0 (no calcification) to 7. Follow-up information on major clinical events (including fatal or nonfatal ischemic stroke, cardiac and peripheral artery events, and all-cause death) was obtained by means of a structured phone interview. Results— IAC was present in 260 patients (83%). With a mean follow-up of 773±223 days, 88 major clinical events occurred in 67 patients (22%): 45 new ischemic vascular events (ischemic stroke: n=22; cardiac event: n=15; peripheral artery event: n=8) and 43 deaths from any cause. Patients with the highest IAC scores had significantly higher rates of death and vascular events than those with the lowest IAC scores (log rank test, P =0.029). In the Cox proportional hazards regression model, the IAC score was significantly associated with major clinical events (hazard ratio, 1.34; 95% CI, 1.11–1.61; P =0.002). Conclusions— In patients with ischemic stroke, IAC detection may constitute a simple marker of a high risk of future major clinical events.
Databáze: OpenAIRE
Externí odkaz: