No role of beta receptors in cognitive flexibility: Evidence from task-switching paradigm in a randomized controlled trial
| Autor: | Bernhard Hommel, M. de Rover, Roberta Sellaro, Laura Steenbergen, Lorenza S. Colzato |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Task switching beta receptors Adrenergic receptor Blood Pressure Propranolol Pharmacology Placebo cognitive flexibility norepinephrine law.invention Young Adult Adrenergic Agents Cognition Propranolol Hydrochloride Double-Blind Method Randomized controlled trial Heart Rate law Receptors Adrenergic beta Reaction Time medicine Humans Attention task-switching Analysis of Variance General Neuroscience Antagonist Cognitive flexibility Acoustic Stimulation Female Cues Psychology Photic Stimulation Psychomotor Performance medicine.drug |
| Zdroj: | Neuroscience, 295, 237-242 |
| Popis: | There is evidence that noradrenergic coeruleo-cortical projections are involved in different forms of cognitive flexibility. So far, no studies in humans have investigated the involvement of beta receptors on task-switching performance, a well-established measure of cognitive flexibility. The present study investigated whether the administration of propranolol (a central and peripheral beta-adrenergic antagonist) affected switching costs (i.e., the increase of reaction time in task-switching trials relative to task-repetition trials). Sixteen healthy adult human subjects performed a global-local task-switching paradigm in a double-blind, within-subjects design study investigating the effects of 80mg of propranolol hydrochloride (a β1 and β2 adrenergic receptor antagonist) vs. an oral dose of microcrystalline cellulose (placebo pill). The acute administration of propranolol did not affect the size of switching costs compared to the intake of the neutral placebo. Our results, corroborated by Bayesian inference, suggest that beta receptors do not modulate cognitive flexibility as measured by task-switching performance. |
| Databáze: | OpenAIRE |
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