Automated electrical source imaging with scalp EEG to define the insular irritative zone: Comparison with simultaneous intracranial EEG
| Autor: | Pieter van Mierlo, Venethia Danthine, Amir Ghasemi Baroumand, Riem El Tahry, Alexane Fierain, Simone Vespa, Pascal Vrielynck, Marianne de Tourtchaninoff, Evelina Iachim, José Géraldo Ribeiro Vaz, Christian Raftopoulos, Susana Ferrao Santos |
|---|---|
| Přispěvatelé: | UCL - SSS/IONS/NEUR - Clinical Neuroscience, UCL - SSS/IONS/CEMO - Pôle Cellulaire et moléculaire, UCL - (SLuc) Service de neurochirurgie, UCL - (SLuc) Service de neurologie, UCL - (SLuc) Centre de référence pour l'épilepsie réfractaire, UCL - (SLuc) Centre de revalidation neuropédiatrique et neuropsychologique infantile, UCL - (SLuc) Centre de lutte contre la douleur |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male Adolescent Clinical Neurology Electroencephalography Stereoelectroencephalography Young Adult Physiology (medical) medicine Humans Epilepsy surgery Ictal Insular Cortex Source imaging Child Aged Retrospective Studies Brain Mapping Epilepsy Scalp medicine.diagnostic_test business.industry Middle Aged Scalp eeg Intracranial eeg Sensory Systems medicine.anatomical_structure Neurology Female Neurology (clinical) Nuclear medicine business |
| Zdroj: | Clinical neurophysiology, Vol. 132, no. 1, p. 2965-2978 (2021) |
| ISSN: | 1872-8952 |
| Popis: | Objective To evaluate the accuracy of automated interictal low-density electrical source imaging (LD-ESI) to define the insular irritative zone (IZ) by comparing the simultaneous interictal ESI localization with the SEEG interictal activity. Methods Long-term simultaneous scalp electroencephalography (EEG) and stereo-EEG (SEEG) with at least one depth electrode exploring the operculo-insular region(s) were analyzed. Automated interictal ESI was performed on the scalp EEG using standardized low-resolution brain electromagnetic tomography (sLORETA) and individual head models. A two-step analysis was performed: i) sublobar concordance between cluster-based ESI localization and SEEG-based IZ; ii) time-locked ESI-/SEEG analysis. Diagnostic accuracy values were calculated using SEEG as reference standard. Subgroup analysis was carried out, based on the involvement of insular contacts in the seizure onset and patterns of insular interictal activity. Results Thirty patients were included in the study. ESI showed an overall accuracy of 53% (C.I. 29–76%). Sensitivity and specificity were calculated as 53% (C.I. 29–76%), 55% (C.I. 23–83%) respectively. Higher accuracy was found in patients with frequent and dominant interictal insular spikes. Conclusions LD-ESI defines with good accuracy the insular implication in the IZ, which is not possible with classical interictal scalp EEG interpretation. Significance Automated LD-ESI may be a valuable additional tool to characterize the epileptogenic zone in epilepsies with suspected insular involvement. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect