Bis-nor-diterpene from Cnidoscolus quercifolius (Euphorbiaceae) induces tubulin depolymerization-mediated apoptosis in BRAF-mutated melanoma cells

Autor:	Raimundo Gonçalves de Oliveira-Júnior, Christiane Adrielly Alves Ferraz, Ana Paula de Oliveira, Edigênia Cavalcante da Cruz Araújo, Grégoire Prunier, Laureen Beaugeard, Hugo Groult, Laurent Picot, Edilson Beserra de Alencar Filho, Noureddine El Aouad, Larissa Araújo Rolim, Jackson Roberto Guedes da Silva Almeida
Rok vydání:	2021
Předmět:	Proto-Oncogene Proteins B-raf Binding Sites Plant Extracts Euphorbiaceae Apoptosis General Medicine Cell Cycle Checkpoints Toxicology Antineoplastic Agents Phytogenic Molecular Docking Simulation Cell Movement Tubulin Cell Line Tumor Mutation Plant Bark Humans Diterpenes Colchicine Melanoma
Zdroj:	Chemico-biological interactions. 355
ISSN:	1872-7786
Popis:	A phytochemical investigation of cytotoxic extract and fractions of Cnidoscolus quercifolius Pohl led to isolation of five terpenoids, including three lupane-type triterpenes (1-3) and two bis-nor-diterpenes (4-5). Compounds 4 (phyllacanthone) and 5 (favelanone) are commonly found in this species and have unique chemical structure. Although their cytotoxic activity against cancer cells has been previously reported, the anticancer potential of these molecules remains poorly explored. In this paper, the antimelanoma potential of phyllacanthone (PHY) was described for the first time. Cell viability assay showed a promising cytotoxic activity (IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19808e373d8f2b815d961b31226e770b https://pubmed.ncbi.nlm.nih.gov/35150652 Zobrazit plný text záznamu Full Text from ScienceDirect