Advanced glycation end products are elevated in estrogen receptor-positive breast cancer patients, alter response to therapy, and can be targeted by lifestyle intervention

Autor: Heidi Varner, Lindsay L. Peterson, Kent Armeson, Michael B. Lilly, Marvella E. Ford, Mathew J. Gregoski, Kendrea D. Knight, Lourdes M. Nogueira, David P. Turner, Marian H. Taylor, Stefan Ambs, Rita Kramer, Tonya F. Turner, Van Phan, Bradley A. Krisanits, Laura Spruill, Jaime Uribarri, Gayenell S. Magwood, King C. Chan, Katherine R. Walter, Mark J. Clair, Shweta Singh, Andrea M. Abbott, Victoria J. Findlay, Elizabeth Garrett-Mayer, Amanda C. La Rue, Ebony J. Hilton
Rok vydání: 2018
Předmět:
Glycation End Products
Advanced
Lifestyle intervention
0301 basic medicine
Oncology
Cancer Research
Estrogen receptor
Disease
chemistry.chemical_compound
Preclinical Study
Breast cancer
0302 clinical medicine
Cancer Survivors
Risk Factors
Glycation
Medicine
Incidence (epidemiology)
Tamoxifen resistance
Middle Aged
Combined Modality Therapy
3. Good health
Treatment Outcome
Receptors
Estrogen
030220 oncology & carcinogenesis
Advanced glycation end-product
Female
Advanced glycation end product
Signal Transduction
medicine.medical_specialty
Antineoplastic Agents
Hormonal
medicine.drug_class
Breast Neoplasms
03 medical and health sciences
Cell Line
Tumor
Internal medicine
Humans
Life Style
Aged
Neoplasm Staging
business.industry
medicine.disease
Tamoxifen
030104 developmental biology
chemistry
Drug Resistance
Neoplasm
Estrogen
Neoplasm Grading
business
Biomarkers
Zdroj: Breast Cancer Research and Treatment
ISSN: 1573-7217
0167-6806
DOI: 10.1007/s10549-018-4992-7
Popis: Purpose Lifestyle factors associated with personal behavior can alter tumor-associated biological pathways and thereby increase cancer risk, growth, and disease recurrence. Advanced glycation end products (AGEs) are reactive metabolites produced endogenously as a by-product of normal metabolism. A Western lifestyle also promotes AGE accumulation in the body which is associated with disease phenotypes through modification of the genome, protein crosslinking/dysfunction, and aberrant cell signaling. Given the links between lifestyle, AGEs, and disease, we examined the association between dietary-AGEs and breast cancer. Methods We evaluated AGE levels in bio-specimens from estrogen receptor-positive (ER+) and estrogen receptor-negative (ER−) breast cancer patients, examined their role in therapy resistance, and assessed the ability of lifestyle intervention to reduce circulating AGE levels in ER+ breast cancer survivors. Results An association between ER status and AGE levels was observed in tumor and serum samples. AGE treatment of ER+ breast cancer cells altered ERα phosphorylation and promoted resistance to tamoxifen therapy. In a proof of concept study, physical activity and dietary intervention was shown to be viable options for reducing circulating AGE levels in breast cancer survivors. Conclusions There is a potential prognostic and therapeutic role for lifestyle derived AGEs in breast cancer. Given the potential benefits of lifestyle intervention on incidence and mortality, opportunities exist for the development of community health and nutritional programs aimed at reducing AGE exposure in order to improve breast cancer prevention and treatment outcomes. Electronic supplementary material The online version of this article (10.1007/s10549-018-4992-7) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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