An Outbreak of a Respiratory Disorder at a Russian Swine Farm Associated with the Co-Circulation of PRRSV1 and PRRSV2

Autor: A G Yuzhakov, Alexandr Bulgakov, Oleg A. Verkhovsky, Sergei A. Raev, Alexei Gerasianinov, T. I. Aliper, Ludmila Kostina, Alexei D. Zaberezhny
Rok vydání: 2020
Předmět:
PCV2
0301 basic medicine
cross-sectional
medicine.medical_specialty
Veterinary medicine
Farms
Genotype
Swine
040301 veterinary sciences
Porcine Reproductive and Respiratory Syndrome
lcsh:QR1-502
Case Report
Viremia
Antibodies
Viral
lcsh:Microbiology
Disease Outbreaks
ORF7
0403 veterinary science
Open Reading Frames
03 medical and health sciences
antibody detection
Virology
Epidemiology
medicine
Animals
Porcine respiratory and reproductive syndrome virus
Respiratory system
Phylogeny
PRRSV1
biology
phylogenetic analysis
Respiratory disease
Respiratory pathogen
Genetic Variation
Outbreak
04 agricultural and veterinary sciences
medicine.disease
Porcine reproductive and respiratory syndrome virus
biology.organism_classification
PRRSV2
Siberia
Cross-Sectional Studies
030104 developmental biology
Infectious Diseases
Zdroj: Viruses, Vol 12, Iss 1169, p 1169 (2020)
Viruses
ISSN: 1999-4915
Popis: We conducted a cross-sectional study to identify the major respiratory pathogen responsible for an outbreak of respiratory disease at a swine farm in West Siberia in 2019. We discovered that the peak of morbidity and mortality coincided with a high level of porcine reproductive and respiratory syndrome virus (PRRSV) 1 and 2-related viremia. Based on longer PRRSV2 viremia, the dominant role of PRRSV2 over PRRSV1 in the outbreak was assumed. Phylogenetic analysis revealed that the PRRSV1 strain belonged to sub-genotype 2—one of the predominant groups of genotype 1 PRRSVs in Russia. A partial open reading frame 7 sequence of the PRRSV2 isolate demonstrated a high identity with modified live vaccine-related strains from Denmark (93%) and wild-type VR2332 (92%). We identified the first instance of PRRSV1/PRRSV2 mixed infection in Russia. This finding indicates that further field investigations are needed to access PRRSV2 epidemiology in eastern Europe.
Databáze: OpenAIRE
Externí odkaz: