Intralesional cryosurgery for the treatment of basal cell carcinoma of the lower extremities in elderly subjects: a feasibility study
| Autor: | Nir Gal-Or, Tamir Gil, Amir Taran, Lior Har-Shai, Judit Krausz, Yaron Har-Shai, Nir Eyal, Adir Sommer, Idit Lavi, Irit Elmalach, Issa Mettanes, Leonid Brizgalin |
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| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Skin Neoplasms Biopsy medicine.medical_treatment Deep vein Pain Dermatology Cryosurgery 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine medicine Carcinoma Humans Basal cell carcinoma Prospective Studies Prospective cohort study Aged Skin Aged 80 and over integumentary system medicine.diagnostic_test business.industry medicine.disease Thrombosis Surgery Treatment Outcome medicine.anatomical_structure Lower Extremity Carcinoma Basal Cell 030220 oncology & carcinogenesis Heart failure Feasibility Studies Female business |
| Zdroj: | International Journal of Dermatology. 55:342-350 |
| ISSN: | 0011-9059 |
| DOI: | 10.1111/ijd.13168 |
| Popis: | Background Incidences of basal cell carcinoma (BCC) on the lower extremities in elderly patients are rising. Surgical approaches to the treatment of BCC are subject to possible difficulties in healing, failure of skin grafts, and wound infection. This study assessed the efficacy of intralesional cryosurgery in the treatment of BCC of the lower limbs in elderly patients. Methods This study included eight patients aged >60 years in whom a total of 10 nodular or superficial BCCs of the lower limbs were confirmed by biopsy. The patients' medical histories revealed comorbidities including hypertension, diabetes, hypercholesterolemia, venous insufficiency, and deep vein thrombosis of the legs, congestive heart failure, chronic renal failure, and ischemic heart disease. Using liquid nitrogen, an intralesional cryosurgery needle (CryoShape) was inserted into the tumor to facilitate its complete freezing. Treatment success was confirmed by biopsy taken approximately 3 months after complete healing of the cryo-wound. Results The average size of the lesions treated was 2.49 cm2 (16.4 × 15.2 mm). Mean recovery time was 79.9 days. Biopsies were obtained at a mean of 85.3 days after the wound had healed. All 10 biopsies verified the complete destruction of the tumor. There was no evidence of wound infection or tumor recurrence over a follow-up period of 28 months. Conclusions This study demonstrates that a single intralesional cryosurgery session can completely eradicate BCC on the lower extremities in elderly patients. This technique is associated with relatively minor complications, is well tolerated, and represents a safe and effective therapeutic modality for BCC of the lower limbs. |
| Databáze: | OpenAIRE |
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