A prognostic index for thyroid carcinoma. A study of the E.O.R.T.C. thyroid cancer cooperative group
| Autor: | Martine van Glabbeke, E.Dillwyn E.D. Williams, David D.P. Byar, Pierre Dor, Richard Sylvester, Sylvan S.B. Green, Henriette H.A. van Gilse, Marcel Mayer, Jacques Colon |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male Risk Oncology medicine.medical_specialty Prognostic variable Multivariate analysis Adolescent law.invention Thyroid carcinoma Sex Factors Randomized controlled trial law Internal medicine medicine Humans Cooperative group Thyroid Neoplasms Neoplasm Metastasis Child Lymph node Thyroid cancer Survival analysis Aged Neoplasm Staging business.industry Age Factors General Medicine Middle Aged Models Theoretical Prognosis medicine.disease medicine.anatomical_structure Female Lymph Nodes business Follow-Up Studies |
| Zdroj: | European Journal of Cancer (1965). 15:1033-1041 |
| ISSN: | 0014-2964 |
| DOI: | 10.1016/0014-2964(79)90291-3 |
| Popis: | Using survival from all causes of death as an endpoint, the prognostic significance of age, sex, cell type, clinical extent of tumor, lymph node status and number of metastatic sites (all recorded at the time of diagnosis) was studied in a set of data for 500 patients with histologically confirmed thyroid carcinoma. Each of these variables was found to have prognostic significance when examined singly, but some were strongly correlated with others. A simple prognostic index based on a multivariate analysis using a Weibull survival model is presented which allows one to assess the joint effects of the prognostic variables and indentifies patients with markedly different survival probabilities. The index may be used to predict survival for individual patients as an adjustment variable in treatment comparisons, or as a stratification variable in designing prospective randomized trials of treatment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|