Genital Cytomegalovirus Replication Predicts Syphilis Acquisition among HIV-1 Infected Men Who Have Sex with Men
| Autor: | Richard Haubrich, Michael P. Dubé, Sara Gianella, Eric S. Daar, Andrea Lisco, Leonid Margolis, Sheldon R. Morris, Davey M. Smith, Christophe Vanpouille |
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| Rok vydání: | 2015 |
| Předmět: |
Human cytomegalovirus
Adult Male General Science & Technology AIDS-Related Opportunistic Infections Gonorrhea Congenital cytomegalovirus infection lcsh:Medicine Cytomegalovirus AIDS-Related Opportunistic Infections/*diagnosis/epidemiology Adult Cytokines/metabolism Cytomegalovirus/isolation & purification/*physiology Cytomegalovirus Infections/*diagnosis/epidemiology Hiv-1 *Homosexuality Male Humans Male Middle Aged Semen/metabolism/*virology Syphilis/*diagnosis/epidemiology *Virus Replication urologic and male genital diseases Virus Replication Men who have sex with men Semen MD Multidisciplinary medicine Humans Sex organ Syphilis Homosexuality Male lcsh:Science Multidisciplinary business.industry lcsh:R virus diseases Middle Aged medicine.disease female genital diseases and pregnancy complications 3. Good health Viral replication Immunology Cytomegalovirus Infections HIV-1 Cytokines lcsh:Q business Research Article |
| Zdroj: | PLoS ONE Gianella, Sara; Smith, Davey M; Daar, Eric S; Dube, Michael P; Lisco, Andrea; Vanpouille, Christophe; et al.(2015). Genital Cytomegalovirus Replication Predicts Syphilis Acquisition among HIV-1 Infected Men Who Have Sex with Men.. PloS one, 10(6), e0130410. doi: 10.1371/journal.pone.0130410. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/9fz911dm PLoS ONE, Vol 10, Iss 6, p e0130410 (2015) |
| ISSN: | 1932-6203 |
| DOI: | 10.1371/journal.pone.0130410. |
| Popis: | Objective Sexually transmitted infections (STI) are common among HIV-infected men who have sex with men (MSM). While behavioral factors are important in STI acquisition, other biological factors such as immune modulation due to chronic viral infection may further predispose to STI acquisition. Design Post Hoc analysis including data collected over 12 months of follow-up from 131 HIV-infected MSM receiving antiretroviral therapy and screened for incident bacterial STI every 3 months. Methods Genital secretions collected at baseline were used to measure herpesvirus replication and inflammatory cytokines. Baseline predictors of STI were determined using survival analysis of time to incident STI. Results All participants were seropositive for cytomegalovirus (CMV), and 52% had detectable genital CMV at baseline. Thirty-five individuals acquired STI during follow-up, sometimes with multiple pathogen (17 syphilis, 21 gonorrhea, 14 chlamydia). Syphilis acquisition was associated with genital CMV replication at baseline (19.1% CMV-shedders versus 4.8% non-shedders, p=0.03) and younger age (p=0.02). Lower seminal MCP-1 was associated with higher seminal CMV levels and with syphilis acquisition (p |
| Databáze: | OpenAIRE |
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