Glutamate and NO mediation of the pressor response to 5-HT3 receptor stimulation in the nucleus tractus solitarii

Autor: Boris Maisonneuve, Raul Laguzzi, Caroline Sévoz-Couche, Michel Hamon
Rok vydání: 2002
Předmět:
Male
Agonist
Serotonin
medicine.medical_specialty
Indazoles
medicine.drug_class
Biguanides
Glutamic Acid
Blood Pressure
Pressoreceptors
AMPA receptor
Nitric Oxide
Receptors
Metabotropic Glutamate
Receptors
N-Methyl-D-Aspartate
Synaptic Transmission
5-HT3 receptor
Rats
Sprague-Dawley
Internal medicine
Reflex
Solitary Nucleus
medicine
Animals
heterocyclic compounds
Enzyme Inhibitors
Neurons
Oxadiazoles
biology
Metabotropic glutamate receptor 5
Chemistry
General Neuroscience
Glutamate receptor
Rats
Serotonin Receptor Agonists
Endocrinology
nervous system
Guanylate Cyclase
Metabotropic glutamate receptor
Receptors
Serotonin
biology.protein
NMDA receptor
Nitric Oxide Synthase
Receptors
Serotonin
5-HT3
Soluble guanylyl cyclase
Excitatory Amino Acid Antagonists
circulatory and respiratory physiology
Zdroj: Neuroreport. 13:837-841
ISSN: 0959-4965
DOI: 10.1097/00001756-200205070-00020
Popis: The possible participation of glutamate and NO/cGMP in the pressor response to 5-HT3 receptor activation in the nucleus tractus solitarii (NTS) was investigated using selective antagonists in urethane-anaesthetized rats. Intra-NTS administration of NMDA and non-NMDA receptor antagonists, but not metabotropic glutamate receptor antagonists, markedly reduced (70%) the increase in blood pressure caused by local application of the potent 5-HT3 receptor agonist, 1-(m-chlorophenyl)-biguanide. The 5-HT3 receptor-mediated pressor response was also significantly attenuated by the local blockade of nitric oxide synthase and soluble guanylyl cyclase. These data suggest that ionotropic glutamate receptors and the associated NO/cGMP transduction mechanism contribute downstream to the pressor effect elicited by 5-HT3 receptor stimulation in the NTS.
Databáze: OpenAIRE
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