A multi-component reaction for the synthesis of pyrido [1,2-b] isoquinoline derivatives via the [3 + 2] cycloaddition reaction between alkynes and in situ generated isoquinolinium ylides

Autor:	Pravin R. Likhar, Soumi Laha, Dharmendra Kumar Tiwari, Sundar S. Shinde, B. Sridhar
Rok vydání:	2019
Předmět:	chemistry.chemical_classification In situ Tandem Organic Chemistry Biochemistry Combinatorial chemistry Cycloaddition chemistry.chemical_compound chemistry Ylide Ninhydrin Multi-component reaction Proline Physical and Theoretical Chemistry Isoquinoline
Zdroj:	Organic & Biomolecular Chemistry. 17:4121-4128
ISSN:	1477-0539 1477-0520
Popis:	An efficient and one-pot tandem procedure for the synthesis of fused ethanopyrido [1,2-b] isoquinoline derivatives from ninhydrin, proline and alkynes has been developed. This strategy exhibits an unprecedented [3 + 2] cycloaddition reaction between alkynes and isoquinolinium ylide (1,3 dipole) generated in situ from proline and ninhydrin. This newly developed methodology features simple operation and is metal free. In this methodology overall three new C-C bonds, two C-N bonds, and three new rings are formed in a single step process.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::197ba2fffc79d6ab32a5bd96d20d87c6 https://doi.org/10.1039/c9ob00560a Zobrazit plný text záznamu