Effects of chronic mild stress on sexual behavior, locomotor activity and consumption of sucrose and saccharine solutions
| Autor: | Chiara M. Portas, Robert Murison, Eldbjørg Fiske, Eli Sørensen, Reidun Ursin, Janne Grønli, Bjørn Bjorvatn |
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| Rok vydání: | 2005 |
| Předmět: |
Male
Sucrose Drinking Behavior Physiology Experimental and Cognitive Psychology Motor Activity Locomotor activity Open field Developmental psychology Rats Sprague-Dawley Food Preferences Sexual Behavior Animal Behavioral Neuroscience chemistry.chemical_compound Saccharin Reward Mild stress health services administration medicine Animals health care economics and organizations Consumption (economics) Analysis of Variance Depression Stressor Anhedonia Rats Disease Models Animal Sexual behavior chemistry Taste Chronic Disease Exploratory Behavior Female medicine.symptom Psychology Stress Psychological psychological phenomena and processes |
| Zdroj: | Physiology & Behavior. 84:571-577 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/j.physbeh.2005.02.007 |
| Popis: | Many symptoms of human depressive disorders are also observed in animals after exposure to unpredictable stressors. The chronic mild stress (CMS) paradigm was developed in order to better model the human situation by using chronic mild stressors over a longer period. It is claimed that the model induces anhedonia in the animals, a core symptom of depression in humans. Despite the fact that the CMS model has a high degree of face validity, there are a number of laboratories in which the establishment of the model is less reliably observed. We have examined behavior (sexual activity and open field activity) together with hedonic measures (sucrose and saccharine intake) after exposure to CMS. CMS decreased male sexual activity (e.g. reduced capability to ejaculate) and increased activity in an open field test. The hedonic measures showed diverging results after CMS in our laboratory. Sucrose consumption was reduced, while saccharine consumption did not show a comparable change. It is concluded that CMS induces comparable alterations to some depression-like symptoms in humans. Saccharine consumption is not a reliable indicator of the hedonic responsiveness to CMS. |
| Databáze: | OpenAIRE |
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