Berberine Attenuates Cholesterol Accumulation in Macrophage Foam Cells by Suppressing AP-1 Activity and Activation of the Nrf2/HO-1 Pathway
Autor: | Ling-Chao Yang, Na Feng, Yong Chen, Fang Liu, Shuang-Xi Zhu, Xiang-Fei Feng, Xue-Juan Yang, Xue-Song Ding |
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Rok vydání: | 2020 |
Předmět: |
CD36 Antigens
0301 basic medicine Berberine Apolipoprotein B Mice Knockout ApoE NF-E2-Related Factor 2 THP-1 Cells Inflammation 030204 cardiovascular system & hematology Cholinergic Antagonists 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Downregulation and upregulation medicine Animals Humans Macrophage Scavenger receptor ATP Binding Cassette Transporter Subfamily G Member 1 Foam cell Pharmacology biology Cholesterol Scavenger Receptors Class A Atherosclerosis Cell biology Lipoproteins LDL Mice Inbred C57BL Transcription Factor AP-1 Disease Models Animal 030104 developmental biology chemistry biology.protein lipids (amino acids peptides and proteins) medicine.symptom Cardiology and Cardiovascular Medicine Heme Oxygenase-1 ATP Binding Cassette Transporter 1 Foam Cells |
Zdroj: | Journal of Cardiovascular Pharmacology. 75:45-53 |
ISSN: | 0160-2446 |
Popis: | Atherosclerosis is a chronic inflammation condition resulting from the interaction between lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in the arterial wall. Macrophage-derived foam cells play a key role in both early and advanced stage of atherosclerosis. Previous studies have shown that berberine could inhibit foam cell formation and prevent experimental atherosclerosis. However, its underlying molecular mechanisms have not been fully clarified. In this study, we explored the cholesterol-lowering effects of berberine in macrophage-derived foam cells and investigated its possible mechanisms in prevention and treatment of atherosclerosis. Here, we demonstrated that berberine could inhibit atherosclerosis in apolipoprotein E-deficient mice and induce cholesterol reduction as well as decrease the content of macrophages. Berberine can regulate oxLDL uptake and cholesterol efflux, thus suppresses foam cell formation. Mechanisms study showed that berberine can suppress scavenger receptor expression via inhibiting the activity of AP-1 and upregulate ATP-binding cassette transporter via activating Nrf2/HO-1 signaling in human macrophage. In summary, berberine significantly inhibits atherosclerotic disease development by regulating lipid homeostasis and suppressing macrophage foam cell formation. |
Databáze: | OpenAIRE |
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