Berberine Attenuates Cholesterol Accumulation in Macrophage Foam Cells by Suppressing AP-1 Activity and Activation of the Nrf2/HO-1 Pathway

Autor: Ling-Chao Yang, Na Feng, Yong Chen, Fang Liu, Shuang-Xi Zhu, Xiang-Fei Feng, Xue-Juan Yang, Xue-Song Ding
Rok vydání: 2020
Předmět:
CD36 Antigens
0301 basic medicine
Berberine
Apolipoprotein B
Mice
Knockout
ApoE
NF-E2-Related Factor 2
THP-1 Cells
Inflammation
030204 cardiovascular system & hematology
Cholinergic Antagonists
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Downregulation and upregulation
medicine
Animals
Humans
Macrophage
Scavenger receptor
ATP Binding Cassette Transporter
Subfamily G
Member 1
Foam cell
Pharmacology
biology
Cholesterol
Scavenger Receptors
Class A
Atherosclerosis
Cell biology
Lipoproteins
LDL
Mice
Inbred C57BL
Transcription Factor AP-1
Disease Models
Animal
030104 developmental biology
chemistry
biology.protein
lipids (amino acids
peptides
and proteins)
medicine.symptom
Cardiology and Cardiovascular Medicine
Heme Oxygenase-1
ATP Binding Cassette Transporter 1
Foam Cells
Zdroj: Journal of Cardiovascular Pharmacology. 75:45-53
ISSN: 0160-2446
Popis: Atherosclerosis is a chronic inflammation condition resulting from the interaction between lipoproteins, monocyte-derived macrophages, T lymphocytes, and other cellular elements in the arterial wall. Macrophage-derived foam cells play a key role in both early and advanced stage of atherosclerosis. Previous studies have shown that berberine could inhibit foam cell formation and prevent experimental atherosclerosis. However, its underlying molecular mechanisms have not been fully clarified. In this study, we explored the cholesterol-lowering effects of berberine in macrophage-derived foam cells and investigated its possible mechanisms in prevention and treatment of atherosclerosis. Here, we demonstrated that berberine could inhibit atherosclerosis in apolipoprotein E-deficient mice and induce cholesterol reduction as well as decrease the content of macrophages. Berberine can regulate oxLDL uptake and cholesterol efflux, thus suppresses foam cell formation. Mechanisms study showed that berberine can suppress scavenger receptor expression via inhibiting the activity of AP-1 and upregulate ATP-binding cassette transporter via activating Nrf2/HO-1 signaling in human macrophage. In summary, berberine significantly inhibits atherosclerotic disease development by regulating lipid homeostasis and suppressing macrophage foam cell formation.
Databáze: OpenAIRE
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