Dyes, trypanosomiasis and DNA: a historical and critical review
| Autor: | Mark Wainwright |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Histology
Trypanosoma congolense Trypanosoma cruzi Suramin Related derivatives Biology HOMIDIUM BROMIDE chemistry.chemical_compound medicine Animals Humans Chagas Disease History 19th Century Hydrogen Bonding DNA Trypan Blue General Medicine History 20th Century South America medicine.disease Trypanocidal Agents Intercalating Agents Phenanthridines Staining Medical Laboratory Technology Trypanosomiasis African chemistry Biochemistry Africa Trypan Red Acridines Cattle Trypan blue Ethidium bromide Azo Compounds Trypanosomiasis medicine.drug |
| Zdroj: | Biotechnic & Histochemistry. 85:341-354 |
| ISSN: | 1473-7760 1052-0295 |
| DOI: | 10.3109/10520290903297528 |
| Popis: | Trypanosomiasis, a group of diseases including sleeping sickness in humans and Nagana in cattle in Africa, and Chagas' disease in South America, remains a considerable problem in the 21(st) century. The therapies that are available, however, usually have their roots in the "dye therapy" of a century ago, knowledge gained at the microscope from parasite staining procedures and converted to chemotherapy based on compounds closely related to the laboratory reagents. Dyes such as trypan red and trypan blue led to the development of suramin, while cationic nitrogen heterocyclic dyes furnished examples of the phenanthridinium class, such as ethidium (homidium) and isometamidium. Both suramin and isometamidium remain in use. Owing to mutagenicity issues, the presence of ethidium among the phenanthridinium dyes has led to concerns over the clinical use of related derivatives. There are several mechanisms for dye-DNA interaction, however, including possible hydrogen bonding of dye to the polymer, and these are discussed together with structure-activity relations and cellular localization of the phenanthridine and isomeric acridines involved. Better understanding of nucleic acid binding properties has allowed the preparation of more effective phenanthridinium analogues intended for use as anticancer/antiviral therapy. |
| Databáze: | OpenAIRE |
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