Formoxanthone C Inhibits Malignant Tumor Phenotypes of Human A549 Multidrug Resistant-cancer Cells through Signal Transducer and Activator of Transcription 1-Histone Deacetylase 4 Signaling
| Autor: | Chutima Kaewpiboon, Nawong Boonnak, Sirichat Kaowinn, Natpaphan Yawut, Young-Hwa Chung |
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| Rok vydání: | 2022 |
| Zdroj: | Journal of Cancer Prevention. 27:112-121 |
| ISSN: | 2288-3657 2288-3649 |
| DOI: | 10.15430/jcp.2022.27.2.112 |
| Popis: | Considering that presence of cancer stem cell (CSC) subpopulation in tumor tissues confers anticancer drug resistance, we investigated whether human A549 lung cancer cells resistant to etoposide possess CSC-like phenotypes. Furthermore, it is known that these malignant tumor features are the leading cause of treatment failure in cancer. We have thus attempted to explore new therapeutic agents from natural products targeting these malignancies. We found that formoxanthone C (XanX), a 1,3,5,6-tetraoxygenated xanthone from |
| Databáze: | OpenAIRE |
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