Host cell modulation of foot-and-mouth disease virus procapsid synthesis
| Autor: | Eduardo Lucio Palma, Alicia Gomez Yafal |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
viruses
Clone (cell biology) Vaccine Production Microbiology Viral infection Virus Cell Line Viral Proteins Aphthovirus Capsid Cricetinae Animals General Veterinary biology urogenital system Virion RNA General Medicine biology.organism_classification Virology Kinetics Cell culture RNA Viral Foot-and-mouth disease virus Cell Division |
| Zdroj: | Veterinary Microbiology. 12:329-335 |
| ISSN: | 0378-1135 |
| DOI: | 10.1016/0378-1135(86)90082-9 |
| Popis: | BHK 21 (clone 13S) cells of high (BHK-SH) and low (BHK-SL) passage number were infected with foot-and-mouth disease virus (FmDV) subtypes A 24 , A 25 and C 3 . While the amount of virus specific RNA produced in BHK-SH cells was 25% of that in BHK-SL cells and the virion production was 27% (C 3 ) to 53% (A 24 ) lower, the synthesis of viral proteins was comparable, associated with an accumulation of procapsids in BHK-SH cells. The results suggest that changes in viral infection pattern with increasing BHK 21 cell passage number should be considered in FMDV vaccine production. |
| Databáze: | OpenAIRE |
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