Effectiveness of laser photoradiation therapy following hematoporphyrin derivative administration in the experimental MS-2 tumor model
| Autor: | Elsa Melloni, Renato Marchesini, Franco Zunino, Giannino Fava, Lucia Locati, Gabriella Pezzoni, Giuseppina Savi |
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| Rok vydání: | 1983 |
| Předmět: |
Cancer Research
Time Factors Derivative Pharmacology 030218 nuclear medicine & medical imaging law.invention 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine law medicine Animals Sensitization Hematoporphyrin Mice Inbred BALB C business.industry Therapeutic effect Dose-Response Relationship Radiation General Medicine Phototherapy medicine.disease Laser Light intensity Hematoporphyrins medicine.anatomical_structure Oncology chemistry Evaluation Studies as Topic 030220 oncology & carcinogenesis Photoradiation Therapy Sarcoma Laser Therapy Sarcoma Experimental business Neoplasm Transplantation |
| Zdroj: | Tumori. 69(4) |
| ISSN: | 0300-8916 |
| Popis: | The effectiveness of laser photoradiation therapy with hematoporphyrin derivative sensitization was tested in the MS-2 sarcoma. This solid tumor, transplanted into the pad of the hind leg of BALB/c mice, was found to be a sensitive experimental model for a quantitative evaluation of response to phototherapy and for determination of critical parameters in laser phototherapy treatment. Under our experimental conditions, optimal therapeutic effects appeared to be critically dependent on drug dose, number of treatments, light intensity, and irradiation of the peripheral border of the tumor. |
| Databáze: | OpenAIRE |
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