Identification and synthesis of major metabolites of Vasopressin V2-receptor agonist WAY-151932, and antagonist, Lixivaptan
| Autor: | John Considine, William DeMaio, Eugene John Trybulski, Kadum Ali, Jian Qi, David Cochran, Lynne Lihotz, Albert John Molinari, Jehan F. Bagli, Susan Christman Croce |
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| Rok vydání: | 2007 |
| Předmět: |
Agonist
Receptors Vasopressin medicine.drug_class Metabolite Clinical Biochemistry Pharmaceutical Science In Vitro Techniques Biochemistry chemistry.chemical_compound Arginine vasopressin receptor 2 Drug Discovery medicine Humans Pyrroles Receptor Molecular Biology Organic Chemistry Antagonist Antidiuretic Hormone Receptor Antagonists Azepines Benzazepines Small molecule Lixivaptan chemistry Benzamides Molecular Medicine |
| Zdroj: | Bioorganicmedicinal chemistry letters. 17(21) |
| ISSN: | 0960-894X |
| Popis: | Small molecule agonists and antagonists of the V(2)-vasopressin receptor have been discovered and have undergone clinical trials. In conjunction with these discovery programs, the synthesis and biological testing of various metabolites associated with these clinical targets were actively pursued. We now report the results of our synthetic efforts and the corresponding biological data generated for several of the metabolites of WAY-151932 and CL-347985 (Lixivaptan). |
| Databáze: | OpenAIRE |
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