Impact of Chronic Hepatitis C Virus Genotype 1b Infection on Triglyceride Concentration in Serum Lipoprotein Fractions

Autor: Munenori Itagaki, Hiroshi Abe, Nobuyoshi Seki, Satoshi Sutoh, Yuta Aida, Yoichi Tomita, Akihito Tsubota, Yoshio Aizawa, Tomonori Sugita, Tomohisa Nagano
Rok vydání: 2015
Předmět:
Liver Cirrhosis
Male
Very low-density lipoprotein
Hepacivirus
very-low-density lipoprotein (VLDL)
Lipoproteins
VLDL
lcsh:Chemistry
chemistry.chemical_compound
Genotype
VLDL sub-fractions
lcsh:QH301-705.5
Spectroscopy
biology
lipoprotein
General Medicine
Computer Science Applications
triglyceride (TG)
Treatment Outcome
Female
lipids (amino acids
peptides
and proteins)
medicine.medical_specialty
Lipoproteins
chronic hepatitis C (CHC)
Antiviral Agents
Article
Catalysis
Inorganic Chemistry
Internal medicine
medicine
Humans
Physical and Theoretical Chemistry
Molecular Biology
Triglycerides
Triglyceride
Cholesterol
business.industry
Organic Chemistry
Hepatitis C
Chronic
medicine.disease
biology.organism_classification
Virology
Endocrinology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
business
hepatitis C virus (HCV)
Biomarkers
Dyslipidemia
Lipoprotein
Chylomicron
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 16, Iss 9, Pp 20576-20594 (2015)
Volume 16
Issue 9
Pages 20576-20594
ISSN: 1422-0067
DOI: 10.3390/ijms160920576
Popis: Reduced low-density lipoprotein (LDL) cholesterol level is a characteristic feature of dyslipidemia in chronic hepatitis C virus (HCV) infection. However, abnormality in serum triglyceride (TG) has not been fully investigated. To clarify the impact of HCV genotype 1b (G1b) infection and advanced fibrosis on serum TG profiles, TG concentrations in lipoprotein fractions were examined in fasting sera from 185 subjects with active or cleared HCV infection by high-performance liquid chromatography. Serum lipoproteins were fractionated into four classes: chylomicron, very low-density lipoprotein (VLDL), LDL, and high-density lipoprotein (HDL). Then, the significance of HCV G1b infection on TG levels in each lipoprotein fraction was determined using multiple regression models. We found that active HCV G1b infection was positively associated with high HDL-TG levels and low VLDL-TG levels, independent of other factors included in the regression model. In VLDL sub-fractions, active HCV infection was only found to be associated with low levels of large VLDL-TG. Similarly, advanced liver fibrosis in chronic HCV G1b infection was associated with high levels of LDL-TG, HDL-TG, and small VLDL-TG, independent of other clinical factors. These findings indicate that active HCV G1b infection and advanced fibrosis are closely associated with abnormal serum TG profiles.
Databáze: OpenAIRE
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