CD40L (CD154) expression in human liver allografts during chronic ductopenic rejection
| Autor: | A S, Gaweco, R H, Wiesner, S, Yong, R, Krom, M, Porayko, G, Chejfec, K D, McClatchey, D H, Van Thiel |
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| Rok vydání: | 1999 |
| Předmět: |
Graft Rejection
Pathology medicine.medical_specialty Kupffer Cells medicine.drug_class medicine.medical_treatment CD40 Ligand chemical and pharmacologic phenomena Liver transplantation Monoclonal antibody Pathogenesis immune system diseases medicine Humans Transplantation Homologous CD40 Antigens CD154 Retrospective Studies Membrane Glycoproteins CD40 Hepatology biology CD68 business.industry Macrophages hemic and immune systems Immunohistochemistry Liver Transplantation Staining Liver Immunology biology.protein Surgery business |
| Zdroj: | Liver Transplantation and Surgery. 5:1-7 |
| ISSN: | 1074-3022 |
| DOI: | 10.1002/lt.500050108 |
| Popis: | The CD40-CD40L (CD154) interaction plays a pivotal role in the effector mechanisms of allograft rejection. Blockade of the CD40/CD40L costimulatory pathway prevents the development of chronic allograft rejection in several animal transplant models. The relevance of in situ CD40 and CD40L expression in human liver allografts was assessed by immunohistochemistry during ductopenic chronic rejection (CR). In CR allograft specimens (n = 8), marked CD40L expression was detected on Kupffer cells (KCs) and sinusoidal macrophages with a unique centrilobular distribution (P |
| Databáze: | OpenAIRE |
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