Effects of spatial attention on mental time travel in patients with neglect

Autor: Shahar Arzy, Stefano Avanzi, Mauro Mancuso, Filomena Anelli, Francesca Frassinetti
Přispěvatelé: Anelli, Filomena, Avanzi, Stefano, Arzy, Shahar, Mancuso, Mauro, Frassinetti, Francesca
Rok vydání: 2017
Předmět:
Male
Chronesthesia
Neuropsychological Tests
computer.software_genre
Functional Laterality
Task (project management)
Correlation
0302 clinical medicine
Thalamus
Voxel
Attention
media_common
Aged
80 and over
Cerebral Cortex
Brain Mapping
05 social sciences
Voxel-based lesion-symptom mapping (VLSM)
Cognition
Spatial attention
Middle Aged
Magnetic Resonance Imaging
Neuropsychology and Physiological Psychology
Italy
Mental time travel
Female
Psychology
Cognitive psychology
Tomography Scanners
X-Ray Computed
media_common.quotation_subject
Cognitive Neuroscience
Experimental and Cognitive Psychology
050105 experimental psychology
Statistics
Nonparametric
Neglect
Perceptual Disorders
03 medical and health sciences
Orientation
Humans
0501 psychology and cognitive sciences
Prismatic adaptation
Aged
Analysis of Variance
Recall
Space Perception
Mental Recall
Time Perception
Insula
computer
030217 neurology & neurosurgery
Zdroj: Cortex; a journal devoted to the study of the nervous system and behavior. 101
ISSN: 1973-8102
Popis: Numerous studies agree that time is represented in spatial terms in the brain. Here we investigate how a deficit in orienting attention in space influences the ability to mentally travel in time, that is to recall the past and anticipate the future. Right brain-damaged patients, with (RBD-N+) and without neglect (RBD-N-), and healthy controls (HC) were subjected to a Mental Time Travel (MTT) task. Participants were asked to project themselves in time to past, present or future (i.e., self-projection) and, for each self-projection, to judge whether events were located relatively in the past or the future (i.e., self-reference). The MTT-task was performed before and after a manipulation, through prismatic adaptation (PA), inducing a leftward shift of spatial attention. Before PA, RBD-N+ were slower for future than for past events, whereas RBD-N- and HC responded similarly to past and future events. A leftward shift of spatial attention by PA reduced the difference in past/future processing in RBD-N+ and fastened RBD-N- and HC's response to past events. Assuming that time concepts, such as past/future, are coded with a left-to-right order on a mental time line (MTL), a recursive search of future-events can explain neglect patients' performance. Improvement of the spatial deficit following PA reduces the recursive search of future events on the rightmost part of the MTL, facilitating exploration of past events on the leftmost part of the MTL, finally favoring the correct location of past and future events. In addition, the study of the anatomical correlates of the temporal deficit in mental time travel through voxel-based lesion-symptom mapping showed a correlation with a lesion located in the insula and in the thalamus. These findings provide new insights about the inter-relations of space and time, and can pave the way to a procedure to rehabilitate a deficit in these cognitive domains.
Databáze: OpenAIRE
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